Triclosan Toothpaste and Third Molar Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

141 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2013-02-28

Brief Summary

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Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

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Detailed Description

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This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Conditions

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Dry Socket Wound Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Interventions

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Colgate Total Toothpaste

Toothbrushing with Colgate Total Toothpaste

Intervention Type OTHER

Colgate Regular Toothpaste

Toothbrushing with Colgate regular toothpaste

Intervention Type OTHER

Other Intervention Names

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triclosan dentifrice fluoride dentifrice

Eligibility Criteria

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Inclusion Criteria

* must include at least one mandibular third molar with partial or full bony impaction
* no sign of active pericoronal (around the crown) infections
* must have not taken antibiotics for any reason in the past 30 days
* must be healthy and between 18 and 35 years of age
* must be able to read and sign an informed consent

Exclusion Criteria

* Subjects with systemic diseases and pregnant or lactating women
* Subjects with advanced periodontal diseases or having two or more untreated caries lesions
* Subjects who cannot read and sign an informed consent
* Subjects with signs of pericoronal infections

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes