Study Results
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Basic Information
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COMPLETED
PHASE2
30 participants
INTERVENTIONAL
2013-11-30
2016-06-30
Brief Summary
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We hypothesize that preoperative rinse with chlorhexidine mouthwash will result in greater reduction of bacterial counts than with essential oil-based, cetylpyridinium chloride, or saline mouthwashes.
The secondary aim of this study is to evaluate the effect of the tested mouthwashes in reducing the bacterial counts over time.
We hypothesize that preoperative rinse with chlorhexidine mouthwash will result in a reduction of bacterial counts for longer duration than with essential oil-based, cetylpyridinium chloride, or saline mouthwashes.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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0.12% Chlorhexidine
Alcohol-free Chlorhexidine Gluconate Oral Rinse USP, 0.12% from GUM®
Mouthwash
An investigator will give the patient the assigned mouthwash based on the randomized group allocation. 30ml of the mouthwash will be given to the subject in a sterilized calibrated tube. The subject will be asked to rinse for 60 seconds. Then, the patient will spit the mouthwash.
Essential oil
LISTERINE® ZERO™ Mouthwash
Mouthwash
An investigator will give the patient the assigned mouthwash based on the randomized group allocation. 30ml of the mouthwash will be given to the subject in a sterilized calibrated tube. The subject will be asked to rinse for 60 seconds. Then, the patient will spit the mouthwash.
0.07% Cetylpyridinium Chloride
Crest Pro-Health Multi-Protection Rinse - Refreshing Clean Mint (Procter and Gamble)
Mouthwash
An investigator will give the patient the assigned mouthwash based on the randomized group allocation. 30ml of the mouthwash will be given to the subject in a sterilized calibrated tube. The subject will be asked to rinse for 60 seconds. Then, the patient will spit the mouthwash.
Saline
Mouthwash
An investigator will give the patient the assigned mouthwash based on the randomized group allocation. 30ml of the mouthwash will be given to the subject in a sterilized calibrated tube. The subject will be asked to rinse for 60 seconds. Then, the patient will spit the mouthwash.
Interventions
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Mouthwash
An investigator will give the patient the assigned mouthwash based on the randomized group allocation. 30ml of the mouthwash will be given to the subject in a sterilized calibrated tube. The subject will be asked to rinse for 60 seconds. Then, the patient will spit the mouthwash.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Aged 18 years and above.
* Partially edentulous.
Exclusion Criteria
* Active infection in the oral cavity.
* Known allergy to any of the agents used in the study.
* Self-reported pregnancy (as the surgical procedure of dental implant placement is elective and typically deferred until after the delivery).
* Fully edentulous.
* Patient with severe periodontitis (Clinical attachment loss of 5mm or more in the majority of intraoral sites).
* Regular use of mouthwashes (once/day).
18 Years
ALL
Yes
Sponsors
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Tufts University
OTHER
Responsible Party
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Locations
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Tufts University School of Dental Medicine Department of Periodontology
Boston, Massachusetts, United States
Countries
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Other Identifiers
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10951
Identifier Type: -
Identifier Source: org_study_id
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