Skin Glue Cesarean Study

NCT ID: NCT05903547

Last Updated: 2025-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-23

Study Completion Date

2025-10-31

Brief Summary

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The aim of this study is to compare cesarean incision outcomes between patients with incision closed with the Dermabond Prineo system compared to standard subcuticular suture.

Detailed Description

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The purpose of this study is to assess patient satisfaction with their incision after undergoing cesarean delivery. Patient satisfaction with their cesarean scar at 4-6 weeks after their surgery will be compared amongst women receiving skin closure with the Dermabond Prineo skin adhesive system versus standard subcuticular suture. Dermabond Prineo has been shown to have improved cosmesis outcomes in non-obstetric populations but has not yet been studied for women receiving cesarean section. In addition to scar appearance, outcomes such as wound infection, postoperative pain, and operative time will be assessed.

Conditions

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Cesarean Section Complication Wound

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Women undergoing cesarean delivery will be recruited and randomized to skin closure with either the Dermabond Prineo system or standard subcuticular suture.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Dermabond Prineo Group

At time of cesarean delivery, patients in the Dermabond Prineo group will undergo skin closure with the Dermabond Prineo skin adhesive system.

Group Type ACTIVE_COMPARATOR

Dermabond Prineo

Intervention Type DEVICE

For subjects in the Dermabond Prineo group, the Dermabond Prineo system will be applied to the skin for skin closure under manufacturer's guidelines.

Suture Group

At time of cesarean delivery, patients in the Suture group will undergo skin closure with standard subcuticular suture.

Group Type PLACEBO_COMPARATOR

Suture

Intervention Type OTHER

For subjects in the Suture group, the skin will be closed with the standard subcuticular suture method.

Interventions

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Dermabond Prineo

For subjects in the Dermabond Prineo group, the Dermabond Prineo system will be applied to the skin for skin closure under manufacturer's guidelines.

Intervention Type DEVICE

Suture

For subjects in the Suture group, the skin will be closed with the standard subcuticular suture method.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women age 18 years or older
* All women scheduled for primary or repeat cesarean deliveries
* All women undergoing intrapartum or antepartum cesarean delivery
* Pfannenstiel skin incision
* Birth of a live infant at time of cesarean delivery

Exclusion Criteria

* Vertical skin incision
* Cesarean hysterectomy
* Emergency or stat cesarean delivery excluding standard preoperative preparation measures (i.e., use of Chlorhexidine skin prep, vaginal prep, etc)
* Intrapartum stillbirth
* Planned postpartum follow up at another facility
* Contraindications to routine postpartum pain medications
* Adhesive or tape allergy
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Columbia University

OTHER

Sponsor Role lead

Responsible Party

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Russell Miller

Sloane Hospital for Women Associate Professor of Prenatal Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Russell Miller, MD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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Columbia University Irving Medical Center/NYP

New York, New York, United States

Site Status

Countries

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United States

References

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Goto S, Sakamoto T, Ganeko R, Hida K, Furukawa TA, Sakai Y. Subcuticular sutures for skin closure in non-obstetric surgery. Cochrane Database Syst Rev. 2020 Apr 9;4(4):CD012124. doi: 10.1002/14651858.CD012124.pub2.

Reference Type BACKGROUND
PMID: 32271475 (View on PubMed)

Dumville JC, Coulthard P, Worthington HV, Riley P, Patel N, Darcey J, Esposito M, van der Elst M, van Waes OJ. Tissue adhesives for closure of surgical incisions. Cochrane Database Syst Rev. 2014 Nov 28;2014(11):CD004287. doi: 10.1002/14651858.CD004287.pub4.

Reference Type BACKGROUND
PMID: 25431843 (View on PubMed)

van de Kar AL, Corion LU, Smeulders MJ, Draaijers LJ, van der Horst CM, van Zuijlen PP. Reliable and feasible evaluation of linear scars by the Patient and Observer Scar Assessment Scale. Plast Reconstr Surg. 2005 Aug;116(2):514-22. doi: 10.1097/01.prs.0000172982.43599.d6.

Reference Type BACKGROUND
PMID: 16079683 (View on PubMed)

Fleisher J, Khalifeh A, Pettker C, Berghella V, Dabbish N, Mackeen AD. Patient satisfaction and cosmetic outcome in a randomized study of cesarean skin closure. J Matern Fetal Neonatal Med. 2019 Nov;32(22):3830-3835. doi: 10.1080/14767058.2018.1474870. Epub 2018 May 24.

Reference Type BACKGROUND
PMID: 29739243 (View on PubMed)

Other Identifiers

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AAAT9584

Identifier Type: -

Identifier Source: org_study_id

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