Patient Reported Experiences and Outcomes Associated with Standard C-Section Wound Closure Versus STRATAFIX/DERMABOND PRINEO Wound Closure (CS-PREO)

NCT ID: NCT06614829

Last Updated: 2024-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-22

Study Completion Date

2025-12-31

Brief Summary

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The aim of the study is to compare outcomes between patients receiving standard C-section wound closure compared to a wound closure bundle that includes Stratafix sutures and Dermabond PRINEO.

Detailed Description

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The purpose of this study is to evaluate patient experience and patient reported outcomes following cesarean delivery in women receiving either standard wound closure or a wound closure bundle which includes both Stratfix sutures and Dermabond Prineo.

Patients in both study arms will complete established questionnaires capturing patient-reported experience measures (PREMS) and patient-reported outcome measures (PROMS).

Conditions

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Cesarean Section; Complications, Wound, Infection (Following Delivery)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Parallel between group study
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Control

This group would be receiving the standard of care.

Group Type NO_INTERVENTION

No interventions assigned to this group

Bundled C-section Wound Closure

Surgeons in this arm will complete elective C-section wound closure with Stratafix Sutures and the Dermabond PRINEO wound dressing.

Group Type ACTIVE_COMPARATOR

Stratafix Suture

Intervention Type DEVICE

Stratafix sutures are barbed and have an antimicrobial coating. The barbs maintain tension during and allows for knotless suturing. The antimicrobial coating inhibits bacterial colonization of the wound.

DERMABOND PRINEO

Intervention Type DEVICE

DERMABOND™ PRINEO™ Skin Closure System is a sterile, liquid topical skin adhesive. It also incorporates a self-adhering mesh that is applied to the approximated skin edges to provide temporary skin edge alignment until the liquid adhesive is applied to achieve skin closure. It forms a strong, flexible, waterproof microbial barrier-as long as the adhesive film remains intact-that falls off naturally after 7-14 days.

Dermabond Prineo system will be applied to the skin for skin closure.

Interventions

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Stratafix Suture

Stratafix sutures are barbed and have an antimicrobial coating. The barbs maintain tension during and allows for knotless suturing. The antimicrobial coating inhibits bacterial colonization of the wound.

Intervention Type DEVICE

DERMABOND PRINEO

DERMABOND™ PRINEO™ Skin Closure System is a sterile, liquid topical skin adhesive. It also incorporates a self-adhering mesh that is applied to the approximated skin edges to provide temporary skin edge alignment until the liquid adhesive is applied to achieve skin closure. It forms a strong, flexible, waterproof microbial barrier-as long as the adhesive film remains intact-that falls off naturally after 7-14 days.

Dermabond Prineo system will be applied to the skin for skin closure.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient must be 18 years of age or older at time of recruitment
2. Patients opting for a planned (elective) C-Section (13-36 weeks gestation) will be eligible to consent.
3. Patients must have internet access and/or a smartphone in order to access the digital platform to complete the study questionnaires
4. Patients must speak and write in English as study questionnaires will only be provided in English
5. Patients must have coverage from the Ontario Health Insurance Plan (OHIP)

Exclusion Criteria

1. Patients assessed by the participating surgeon with any conditions that may compromise their:

* Ability to consent or use the virtual care platform (e.g., patients with intellectual disabilities)
* Expectation of significant maternal complications that may affect the surgery
2. Patients who enroll in the study but have an unplanned emergency C-section
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Johnson & Johnson

INDUSTRY

Sponsor Role collaborator

North York General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Patricia Trbovich

Badeau Family Research Chair in Patient Safety and Quality Improvement

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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North York General Hospital

North York, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Mark Fan, MHSc

Role: CONTACT

416-756-6000

Facility Contacts

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Mark Fan

Role: primary

416-756-6000

Other Identifiers

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0434

Identifier Type: -

Identifier Source: org_study_id