Efficacy and Acceptability of the Luna EMG Rehabilitation Robot on Motor Recovery of the Upper Limb in the Chronic Phase of Stroke

NCT ID: NCT05902910

Last Updated: 2025-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-12

Study Completion Date

2026-06-12

Brief Summary

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Recent work on large cohorts of chronic stroke (\>6 months post-stroke) have shown that intensive training of the upper limb in the chronic stroke patients can lead to substantial motor and functional gains that are maintained at 6 months post intervention.

A very prolonged (12 weeks) and very intensive (5 hours daily) training applied to chronic patients after stroke brings a substantial gain both motor and functional which is maintained at 3 months post intervention.

Robotic rehabilitation have been shown to be as effective as any other treatment used in rehabilitation. But the methods of implementation remain widely debated. At that time, most robotic therapies have tried to reproduce functional movement mainly pointing objects.

We want to demonstrate that analytic movements of the elbow and the shoulder performed with the Luna-EMG robot can replace part of usual physiotherapy treatment with at least the same effectiveness on the recovery of fluid movements of the upper limb after a stroke.

Detailed Description

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This is a pilot study following a single case experimental design with multiple baselines across subjects (MBD).

People included in the protocol will benefit from 2 hours of daily treatment during 6 to 7.5 weeks. The first 2 weeks will be dedicated to baseline measurement of their upper limb (UL) status with daily treatment for balance and gait control without any treatment of the upper limb. The rest of the time will be dedicated to upper limb treatment exclusively. It will be divided into 2 UL training periods, one of them including a 30mn treatment with the luna EMG robot. The duration of second period will be randomly defined between 2 to 3.5 weeks and the last period will last 2 weeks. The treatment during the first UL treatment period will be randomly allocated to Luna EMG treatment or not. The next period will thus follow the inverse scheme (without if the first contains Luna EMG treatment). The fluidity will be assessed through pointing movements assessed every two days. Evaluation of motor deficiency (Fugl Meyer) and functional status (ARAT score) of the UL will be weekly assessed after the inclusion visit. 3D motion analysis of the UL will also be weekly performed.

All patients will benefit from a regular follow-up and from an organized care protocol. The sessions will be intensive, all subjects will be able to benefit from the new treatment (LUNA EMG). We can expect a direct individual benefit from the proposed intensive treatment, at least for precision of UL movements.

Conditions

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Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

The multiple-baseline SCED design is a prospective design that allows the intensive study of a few individuals to measure their baseline and condition related to a therapeutic intervention. Each subject is his own control with repeated measurements of the primary endpoint. Randomization in the MBD formats of SCED studies relates to the duration of the phases. The experimental plan includes 3 rehabilitation phases: A (Baseline), B (1.5hours a day 5/7 of conventional rehabilitation and 30mn of training with the Luna robot 5/7) and C (2 hours a day 5/7 of conventional rehabilitation). The duration of phase A is fixed (2 weeks). As the effect of the treatment on the upper limb is unknown in its latency, the duration of the second phase of the study will be randomized (2 to 3.5 weeks). Finally, the duration of the third phase is fixed (2 weeks)
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors
Assessors will not know what phase the patient is in at the time of assessment or what experimental design the patient was randomized to.

Study Groups

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Experimental Scheme : A,B,C

The phase B treatment (1.5 hours a day, 5/7 days of conventional rehabilitation and 30mn a day, 5/7 days of treatment with the robot) is scheduled before phase C (2 hours a day, 5/7 days of conventional rehabilitation). The duration of phase B is randomized between 6 and 11 evaluations (2 to 3.5 weeks).

Group Type ACTIVE_COMPARATOR

LUNA-EMG Robot

Intervention Type DEVICE

During phase B, patients will benefit from functional rehabilitation of their upper limbs and from 30mn of training assisted by the LUMA-EMG robot.

Experimental Scheme : A,C,B

The phase C treatment (2 hours a day, 5/7 days of conventional rehabilitation) is scheduled before phase B (1.5 hours a day, 5/7 days of conventional rehabilitation and 30mn a day, 5/7 days of treatment with the robot). The duration of phase C is randomized between 6 and 11 evaluations (2 to 3.5 weeks).

Group Type ACTIVE_COMPARATOR

LUNA-EMG Robot

Intervention Type DEVICE

During phase B, patients will benefit from functional rehabilitation of their upper limbs and from 30mn of training assisted by the LUMA-EMG robot.

Interventions

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LUNA-EMG Robot

During phase B, patients will benefit from functional rehabilitation of their upper limbs and from 30mn of training assisted by the LUMA-EMG robot.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age \>= 18 years
* Hemiparesis after a first stroke with more than 1 year time interval
* Functional upper limb: ability to do a pointing task at 90% of the hand-acromion distance (free trunk).
* Spastic hypertonia of the elbow flexors 0-2/4 on the Modified Ashworth scale
* Patient affiliated with social security
* Patient having signed a consent to participate in the research

Exclusion Criteria

* Inability to sign written consent
* Flexed elbow \> 30° during passive mobilization of the upper limb
* EVA\>3 in the upper limb at rest or during mobilization
* Complete loss of upper limb proprioception
* Neuro-orthopedic surgery of the upper limb for spasticity: neurotomy, tenotomy, transfer
* Pregnant or breastfeeding woman
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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EGZOTech

INDUSTRY

Sponsor Role collaborator

University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Olivier Remy-Neris, PU-PH

Role: PRINCIPAL_INVESTIGATOR

CHRU Brest

Locations

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CHU Brest

Brest, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Olivier Remy-Neris, PU-PH

Role: CONTACT

+33 2 98 22 31 52

Gwenaël Cornec, MD

Role: CONTACT

Facility Contacts

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Olivier Remy-Neris, PU-PH

Role: primary

+332 98 22 31 52

Other Identifiers

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2022-A00096-37

Identifier Type: OTHER

Identifier Source: secondary_id

29BRC21.0393

Identifier Type: -

Identifier Source: org_study_id

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