BACTERIUM: Study for a Machine-learning-based Model to Predict Bloodstream Infections

NCT ID: NCT05876598

Last Updated: 2025-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-03

Study Completion Date

2025-12-30

Brief Summary

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An increase of healthcare-associated infections caused by multidrug- resistant organisms (MRDO) is currently observed. One of the main causes of the emergence of a MDRO infection is an overuse of antibiotics. Therefore, saving useless antibiotic treatment is currently a priority from a public health point of view. The evaluation of the risk of having a bloodstream infection will allow both activating faster treatment decisions (when the risk is significantly high) or to save useless resources in terms of diagnostic tests and treatments, also limiting the potential for side effects (when the risk is significantly low).

Detailed Description

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Conditions

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Infection, Bloodstream

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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antibiotic treatments

The outcome of the study will be to implement Prediction Models to support clinicians for the assessment of risk of having a bloodstream infection.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. adult patients hospitalized at the Gemelli Polyclinic Foundation
2. having at least one performed blood culture
3. starting an antibiotic therapy

Exclusion Criteria

1. blood cultures with contaminants
2. \<18 years old
3. died after less than 48 hours from blood cultures positivity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rita Murri

Role: PRINCIPAL_INVESTIGATOR

Fondazione Policlinico Universitario A. Gemelli, IRCCS

Locations

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Fondazione Policlinico Agostino Gemelli Irccs

Rome, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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rita murri

Role: CONTACT

003930154945

Facility Contacts

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RITA MURRI

Role: primary

00390639154945

Other Identifiers

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BACTERIUM-4407

Identifier Type: -

Identifier Source: org_study_id

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