Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals
NCT ID: NCT05871476
Last Updated: 2025-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
800 participants
INTERVENTIONAL
2022-07-01
2026-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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Intervention district
An information, communication, education and hygiene intervention, developed in collaboration with local health authorities, will aim to improve hygiene and decrease antibiotic use.
, Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention
The intervention will focus on two main measurable outcomes: 1) Decrease feco-oral-animal transmission route to prevent in-HH and community spread of CRE +/- CoRE. 2) Decrease unindicated community use of ABs for humans and animals. This WP focuses on a one health intervention in collaboration with local health authorities, developing and implementing an HH Education Communication Hygiene Intervention (HECHI) to improve HH hygiene and health management and reduce the risk of transmission between humans and animals, a Provider Engagement Intervention (PEI) to improve case management of common infection and decrease unindicated AB, and and a Livestock AB Intervention (LAI) to reduce the use of AB in livestock through improved biosecurity conditions and animal husbandry.
cohort care at the hospital
A laminated note (yellow for "suspicious CRE carrier": green for (CRE-) patients and red for (CRE+) patients) should be put on the front of the patients' bed.
Hospital Cohort Care Intervention at the hospital
There will be 3 different cohort groups for the patients: 1) Unknown CRE colonisation status with increased barrier precautions (all patients until screening results arrive will belong to this group unless there are available screening results from referral hospital), 2) CREpos, and 3) CREneg. CREpos patients (2) will be treated in one area of the ICUs by specially assigned nurses/personnel.
Interventions
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Hospital Cohort Care Intervention at the hospital
There will be 3 different cohort groups for the patients: 1) Unknown CRE colonisation status with increased barrier precautions (all patients until screening results arrive will belong to this group unless there are available screening results from referral hospital), 2) CREpos, and 3) CREneg. CREpos patients (2) will be treated in one area of the ICUs by specially assigned nurses/personnel.
, Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention
The intervention will focus on two main measurable outcomes: 1) Decrease feco-oral-animal transmission route to prevent in-HH and community spread of CRE +/- CoRE. 2) Decrease unindicated community use of ABs for humans and animals. This WP focuses on a one health intervention in collaboration with local health authorities, developing and implementing an HH Education Communication Hygiene Intervention (HECHI) to improve HH hygiene and health management and reduce the risk of transmission between humans and animals, a Provider Engagement Intervention (PEI) to improve case management of common infection and decrease unindicated AB, and and a Livestock AB Intervention (LAI) to reduce the use of AB in livestock through improved biosecurity conditions and animal husbandry.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
24 Months
ALL
Yes
Sponsors
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Linkoeping University
OTHER_GOV
Karolinska Institutet
OTHER
Universität Tübingen
OTHER
University of Copenhagen
OTHER
National Children's Hospital, Vietnam
OTHER
Centre de coopération internationale en recherche agronomique pour le développement (CIRAD)
UNKNOWN
International Centre for Antimicrobial Resistance Solutions
UNKNOWN
Hanoi University of Public Health
OTHER
Responsible Party
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Pham-Duc Phuc
Deputy Director of Center for Public Health and Ecosystem Research
Principal Investigators
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Mattias Larsson, MD
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet
Thirumalaisamy Velavan, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Tübingen, Germany
Håkan Hanberger
Role: STUDY_DIRECTOR
Linkoeping University
Flavie Goutard, PhD
Role: PRINCIPAL_INVESTIGATOR
CIRAD, France
Yaovi Mahuton Gildas Hounmanou, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Copenhagen
Minh-Dien Tran
Role: PRINCIPAL_INVESTIGATOR
Vietnam National Children's Hospital
Locations
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Thai Binh Pediatric Hospital
Thái Bình, Thai Binh, Vietnam
Countries
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Central Contacts
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Facility Contacts
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Thi Nhu Pham, MD
Role: primary
Other Identifiers
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JPIAMR 2021-195
Identifier Type: -
Identifier Source: org_study_id
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