Cohort Study on Biomarkers and Clinical Treatment of Tinnitus
NCT ID: NCT05871294
Last Updated: 2023-05-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2023-02-01
2024-12-31
Brief Summary
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* What are the biomarkers of tinnitus patients？
* How do these biomarkers change during treatment and is there a good correlation with behavioral outcomes? Participants will be asked to complete audiological examination, tinnitus assessment, and magnetoencephalography examination, and they will receive sound therapy or repetitive transcranial magnetic stimulation therapy.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Acoustic stimulation therapy
Patients in this group will receive acoustic stimulation therapy.
Acoustic stimulation
The sound used for treatment is selected based on the patient's tinnitus frequency and loudness. Patients receive 90 minutes of acoustic stimulation therapy every day (at least 5 days per week). The entire treatment period is 3 months.
Repetitive transcranial magnetic stimulation therapy
Patients in this group will receive repetitive transcranial magnetic stimulation therapy.
Repetitive transcranial magnetic stimulation
The course of repeated transcranial magnetic stimulation therapy is 4 weeks, with 5, 5, 4, and 3 treatments per week, each lasting 90 minutes (including rest time)
Interventions
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Acoustic stimulation
The sound used for treatment is selected based on the patient's tinnitus frequency and loudness. Patients receive 90 minutes of acoustic stimulation therapy every day (at least 5 days per week). The entire treatment period is 3 months.
Repetitive transcranial magnetic stimulation
The course of repeated transcranial magnetic stimulation therapy is 4 weeks, with 5, 5, 4, and 3 treatments per week, each lasting 90 minutes (including rest time)
Eligibility Criteria
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Inclusion Criteria
2. The otoscopy examination showed that the ear canal and eardrum were normal, and the tympanic impedance maps of both ears were Type A, indicating that language ability met the requirements of language testing
Exclusion Criteria
2. Suffering from major physical diseases (sensory and motor disorders, neurological disorders, brain injuries, and other organic diseases) or mental disorders
3. The patient has aggressive behavior and an impulse to damage the device
4. Metal in the body (including orthodontics, dental implants), tattoos, and heart stent surgery
5. Having claustrophobia
6. Contraindications to magnetic resonance examination
65 Years
ALL
Yes
Sponsors
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Zhiwu Huang, Ph.D.
OTHER
Responsible Party
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Zhiwu Huang, Ph.D.
Professor, PHD, Director of the Hearing Center
Principal Investigators
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Zhiwu Huang
Role: PRINCIPAL_INVESTIGATOR
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Locations
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Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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SH9H-2022-T379-1
Identifier Type: -
Identifier Source: org_study_id
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