dTDI During a SBT to Predict Extubation Failure in Preterm Infants

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-02-25

Study Completion Date

2024-12-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The External Diaphragm Pacemaker Assisted Extubation in Premature Infants With Invasive Mechanical Ventilation

NCT06404294

Invasive Mechanical Ventilation Extubation

RECRUITING NA

Pressure-Sensing Mattresses and Mechanical Ventilation Weaning in Neonatal

NCT06579157

Bronchopulmonary Dysplasia

RECRUITING

A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation

NCT03181958

Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies

COMPLETED NA

Extubation Readiness Study in Very Low Birthweight Infants

NCT01471431

Respiratory Distress Syndrome

TERMINATED NA

Ultrasound for Assessment of Extubation Readiness

NCT04957264

Mechanical Ventilation Complication Premature Birth

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Premature

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

the failure group

Re-intubation within 48 h after passing the SBT was defined as failed weaning.

diaphragmatic tissue Doppler imaging，dTDI

Intervention Type DEVICE

dTDI was performed at the end of the SBT to assess excursion, velocity, and acceleration.

the success group

Extubation and invasive mechanical ventilation was not needed within 48 h after extubation was defined as successful weaning.

diaphragmatic tissue Doppler imaging，dTDI

Intervention Type DEVICE

dTDI was performed at the end of the SBT to assess excursion, velocity, and acceleration.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

diaphragmatic tissue Doppler imaging，dTDI

dTDI was performed at the end of the SBT to assess excursion, velocity, and acceleration.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* premature infants with gestational age \<32 weeks and supported by invasive mechanical ventilation ≥48 hours
* All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP \< 8cmH2O, RR \< 30 times/min, FiO2 \< 30%; Arterial blood gas: pH \> 7.25, (PaCO2\< 60mmHg, BE \< 8mmol/L, oxygen saturation \> 90%
* a successful SBT
* parents or legal guardians sign informed consent to attend this study

Exclusion Criteria

* accidental extubation
* chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
* complex congenital heart disease
* congenital metabolic diseases, neuromuscular diseases
* severe brain injury
* surgical mechanical ventilation
* give up before extubation;
* pneumothorax or pleural effusion
* no consent is signed

Minimum Eligible Age

2 Days

Maximum Eligible Age

6 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No