Can Food Timing Reduce Your Diabetes Risk?

NCT ID: NCT05862818

Last Updated: 2025-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-12-10

Study Completion Date

2028-06-30

Brief Summary

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The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants.

Participants will:

* complete 2 inpatient stays
* be provided with test meals
* have frequent blood draws

Detailed Description

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The investigators aim to investigate the influence of different food timing, without changing 24-h caloric and nutrient intake, on glucose and fat tolerance and energy expenditure in healthy people on a simulated day or night shift.

Conditions

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Dietary Habits

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Day shift protocol with diet A

Day shift protocol with diet A condition. Since this is a single-blind study, the details of the meal conditions cannot be released during the recruitment stage but will be made public once enrollment closes.

Group Type EXPERIMENTAL

Day shift protocol - Diet order A-B

Intervention Type BEHAVIORAL

Research participants will be assigned to day shift condition and Diet A-B order condition.

Day shift protocol - Diet order B-A

Intervention Type BEHAVIORAL

Research participants will be assigned to day shift condition and Diet B-A order condition.

Day shift protocol with diet B

Day shift protocol with diet B condition. Since this is a single-blind study, the details of the meal conditions cannot be released during the recruitment stage but will be made public once enrollment closes.

Group Type EXPERIMENTAL

Day shift protocol - Diet order A-B

Intervention Type BEHAVIORAL

Research participants will be assigned to day shift condition and Diet A-B order condition.

Day shift protocol - Diet order B-A

Intervention Type BEHAVIORAL

Research participants will be assigned to day shift condition and Diet B-A order condition.

Night shift protocol with diet A

Night shift protocol with diet A condition. Since this is a single-blind study, the details of the meal conditions cannot be released during the recruitment stage but will be made public once enrollment closes.

Group Type EXPERIMENTAL

Night shift protocol - Diet order A-B

Intervention Type BEHAVIORAL

Research participants will be assigned to simulated night shift condition and Diet A-B order condition.

Night shift protocol - Diet order B-A

Intervention Type BEHAVIORAL

Research participants will be assigned to simulated night shift condition and Diet B-A order condition.

Night shift protocol with diet B

Night shift protocol with diet B condition. Since this is a single-blind study, the details of the meal conditions cannot be released during the recruitment stage but will be made public once enrollment closes.

Group Type EXPERIMENTAL

Night shift protocol - Diet order A-B

Intervention Type BEHAVIORAL

Research participants will be assigned to simulated night shift condition and Diet A-B order condition.

Night shift protocol - Diet order B-A

Intervention Type BEHAVIORAL

Research participants will be assigned to simulated night shift condition and Diet B-A order condition.

Interventions

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Day shift protocol - Diet order A-B

Research participants will be assigned to day shift condition and Diet A-B order condition.

Intervention Type BEHAVIORAL

Day shift protocol - Diet order B-A

Research participants will be assigned to day shift condition and Diet B-A order condition.

Intervention Type BEHAVIORAL

Night shift protocol - Diet order A-B

Research participants will be assigned to simulated night shift condition and Diet A-B order condition.

Intervention Type BEHAVIORAL

Night shift protocol - Diet order B-A

Research participants will be assigned to simulated night shift condition and Diet B-A order condition.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy with no acute or chronic medical and psychiatric disorders
* BMI: 18.5-29.9 kg/m2

Exclusion Criteria

* Smokers, current tobacco or e-cigarette use
* Drug or alcohol dependency
* Pregnant
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Brigham and Women's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Frank AJL Scheer, PhD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Frank Scheer, PhD

Role: PRINCIPAL_INVESTIGATOR

Brigham and Women's Hospital

Locations

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Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Ioannis Lempesis, MD, PhD, PhD

Role: CONTACT

6177326256

Facility Contacts

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Frank Scheer, PhD

Role: primary

617-732-14

Other Identifiers

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2023P001063

Identifier Type: -

Identifier Source: org_study_id

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