Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-01

Study Completion Date

2026-08-01

Brief Summary

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This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.

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Detailed Description

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Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.

Conditions

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Motor Cortex Motor Skills

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Single-pulse TMS over the primary motor cortex

We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.

Group Type EXPERIMENTAL

Transcranial Magnetic Stimulation (TMS)

Intervention Type DEVICE

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Paired-pulse TMS over the primary motor cortex

We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task.

Group Type EXPERIMENTAL

Transcranial Magnetic Stimulation (TMS)

Intervention Type DEVICE

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Sham TMS over the primary motor cortex

We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task.

Group Type SHAM_COMPARATOR

Transcranial Magnetic Stimulation (TMS)

Intervention Type DEVICE

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Interventions

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Transcranial Magnetic Stimulation (TMS)

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18-40 years old
* Able to read, understand, and sign the informed consent in English
* Right-handed

Exclusion Criteria

* A sensory or physical impairment
* History of epilepsy or seizures in the family
* Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
* A head injury with loss of consciousness
* Diagnosis of psychiatric or neurological disorder
* Skin defects or active infections on the scalp or hands
* Pregnancy or breastfeeding

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes