Transcranial Magnetic Stimulation in the Rehabilitation of Postoperative Motor Dysfunction.

NCT ID: NCT04706338

Last Updated: 2021-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-15

Study Completion Date

2022-01-01

Brief Summary

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This study focused on glioma patients with postoperative motor deficits, especially for patients with supplementary motor area syndrome. The investigators want to investigate whether the recovery of motor function will be accelerated by using transcranial magnetic stimulation to stimulate primary motor area and supplementary motor area on the lesional hemisphere.

Detailed Description

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Conditions

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Glioma Postoperative Motor Deficit

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

patients with postoperative motor deficits, especially for patients with SMA syndrome.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TMS treatment

Patients with TMS treatment

Group Type EXPERIMENTAL

TMS treatment

Intervention Type DEVICE

Using TMS to stimulate (5 Hz, 90%\~110% resting motor threshold) patients' primary motor area and SMA.

Interventions

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TMS treatment

Using TMS to stimulate (5 Hz, 90%\~110% resting motor threshold) patients' primary motor area and SMA.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. patient underwent awake craniotomy and motor functional identification during tumor resection;
2. patients with postoperative motor deficit (muscle strength of limbs is weaker than preoperative status)

Exclusion Criteria

1. patients with contraindication of transcranial magnetic stimulation;
2. patients without data of the pre- and postoperative resting state MRI and diffusion tensor image.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Neurosurgical Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jiang Tao

Role: STUDY_CHAIR

Beijing Neurosurgical Institute

Locations

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Beijing Neurosurgical Institute and Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shengyu Fang, MD

Role: CONTACT

+8613466331405

Yinyan Wang, MD

Role: CONTACT

+8613581688953

Facility Contacts

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Tao Jiang, MD and PhD

Role: primary

+86-010-67021832

References

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Dionisio A, Duarte IC, Patricio M, Castelo-Branco M. The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review. J Stroke Cerebrovasc Dis. 2018 Jan;27(1):1-31. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.008. Epub 2017 Oct 27.

Reference Type BACKGROUND
PMID: 29111342 (View on PubMed)

Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipovic SR, Grefkes C, Hasan A, Hummel FC, Jaaskelainen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorova I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018). Clin Neurophysiol. 2020 Feb;131(2):474-528. doi: 10.1016/j.clinph.2019.11.002. Epub 2020 Jan 1.

Reference Type BACKGROUND
PMID: 31901449 (View on PubMed)

Other Identifiers

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KY-2020-128-01

Identifier Type: -

Identifier Source: org_study_id

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