Pattern of Intestinal Parasitic Infection Among Cirrhotic Patients in Sohag University Hospital
NCT ID: NCT05856721
Last Updated: 2023-05-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
200 participants
INTERVENTIONAL
2023-06-30
2024-06-30
Brief Summary
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Intestinal parasitic diseases have been reported in association with diabetes mellitus (DM) which is considered a predisposing factor to infection in cirrhotic patients . Immunosuppression among DM cases is due to increased blood glucose levels, which modifies several immune responses and this renders the body susceptible to various opportunistic infections comprising parasitic infections
Intestinal parasites such as Blastocystis hominis, Cryptosporidium spp., Isospora belli, Cyclospora cayetanensis, and Microsporidia have appeared as significant opportunistic parasites that are responsible for severe illness in immunocompromised patients , subsequently, patients suffer from severe morbidity and high mortality).
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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cases group
One hundred patients with liver cirrhosis and GIT complaints
stool analysis
Detection of prevalence and pattern of intestinal parasitic infection in cirrhotic patients and the difference between cirrhotic patients and non-cirrhotic patients with no comorbidity.
To determine the most common risk factors of intestinal parasitic infection in cirrhotic patients.
control group
One hundred patients with GIT complaints but not have any cormobidity
stool analysis
Detection of prevalence and pattern of intestinal parasitic infection in cirrhotic patients and the difference between cirrhotic patients and non-cirrhotic patients with no comorbidity.
To determine the most common risk factors of intestinal parasitic infection in cirrhotic patients.
Interventions
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stool analysis
Detection of prevalence and pattern of intestinal parasitic infection in cirrhotic patients and the difference between cirrhotic patients and non-cirrhotic patients with no comorbidity.
To determine the most common risk factors of intestinal parasitic infection in cirrhotic patients.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* . Cirrhotic patients with cardiac diseases.
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Nada Nady Abdelaal
residant at Tropical Medicine & Gastroenterology departmrnt sohag university
Locations
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Sohag university hospital
Sohag, , Egypt
Countries
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Central Contacts
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Asmaa N Mohamed, professor
Role: CONTACT
Facility Contacts
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Magdy M Amin, professor
Role: primary
References
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Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010 Oct;139(4):1246-56, 1256.e1-5. doi: 10.1053/j.gastro.2010.06.019. Epub 2010 Jun 14.
Bernardi M, Moreau R, Angeli P, Schnabl B, Arroyo V. Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis. J Hepatol. 2015 Nov;63(5):1272-84. doi: 10.1016/j.jhep.2015.07.004. Epub 2015 Jul 17.
Bonnel AR, Bunchorntavakul C, Reddy KR. Immune dysfunction and infections in patients with cirrhosis. Clin Gastroenterol Hepatol. 2011 Sep;9(9):727-38. doi: 10.1016/j.cgh.2011.02.031. Epub 2011 Mar 11.
El-Shazly LB, El-Faramawy AA, El-Sayed NM, Ismail KA, Fouad SM. Intestinal parasitic infection among Egyptian children with chronic liver diseases. J Parasit Dis. 2015 Mar;39(1):7-12. doi: 10.1007/s12639-013-0346-x. Epub 2013 Sep 3.
Other Identifiers
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Soh-Med-23-04-13MS
Identifier Type: -
Identifier Source: org_study_id
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