Serum Ferritin as a Non-invasive Marker in Prediction of Hepatic Fibrosis Among NAFLD Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

113 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study was designed to assess the relation between serum ferritin and hepatic fibrosis in patients with NAFLD. It included 83 patients with NAFLD with or without hepatic fibrosis, in addition to 30 healthy subjects included as controls. Measurement of serum ferritin and its correlation with steatosis and fibrosis was done.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Association Between Serum Ferritin Level and Severity of Liver Disease and Development of HCC in Cirrhotic Patients

NCT05401890

HCC

UNKNOWN

Observational Study About Patients Diagnosed With NAFLD

NCT05625750

Nonalcoholic Fatty Liver Disease

RECRUITING

Relation Between NAFLD and BM DENSITY

NCT06038253

NAFLD Osteoporosis

NOT_YET_RECRUITING

68Ga-FAPI PET/CT in Liver Fibrosis Patients

NCT04533828

Liver Fibrosis Positron Emission Tomography

UNKNOWN EARLY_PHASE1

Liver Fibrosis and Steatosis in dm Non Invasive Evaluation

NCT05605717

Liver Diseases

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Background: many studies have found a relationship between hepatic iron, serum ferritin and NAFLD or its progress. Aim of the work: is to assess the value of serum ferritin as a non-invasive marker in prediction of hepatic fibrosis in NAFLD. Methods: This study included 113 subjects who were classified into 3 groups. Group I: included 30 healthy subjects as control with no evidence of NAFLD by liver biopsy. Group II: included 31 NAFLD patients without fibrosis proved by liver biopsy. Group III: included 52 patients with hepatic fibrosis on top of NAFLD proved by liver biopsy. Serum ferritin was determined using Ferritin ELISA kit. FIB4 was calculated and liver biopsy was done for all patients.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Non-Alcoholic Fatty Liver Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

control group

serum ferritin

Intervention Type DIAGNOSTIC_TEST

serum samples and ferritin ELISA test

NAFLD patients without hepatic fibrosis

serum ferritin

Intervention Type DIAGNOSTIC_TEST

serum samples and ferritin ELISA test

NAFLD patients with hepatic fibrosis

serum ferritin

Intervention Type DIAGNOSTIC_TEST

serum samples and ferritin ELISA test

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

serum ferritin

serum samples and ferritin ELISA test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* adult patients with NAFLD with or without hepatic fibrosis

Exclusion Criteria

* Significant alcohol consumption, other causes of liver disease such as viral hepatitis, schistosomiasis, autoimmune, hereditary, drug induced, or decompensated liver cirrhosis.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes