Evaluation of Hepatic Fibrosis on Multiparametric MRI

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

49 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-04

Study Completion Date

2021-12-31

Brief Summary

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As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.

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Detailed Description

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Conditions

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Cirrhosis Hepatitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Liver MRI

Liver MRI including noncontrast (precontrast) flow measurement, DCE, DWI using multiple b-values, MRE and MR fat quantification.

Group Type EXPERIMENTAL

Liver MRI

Intervention Type DIAGNOSTIC_TEST

Multiparametric Liver MRI including following sequences: DCE, DWI, MRE, precontrast flow measurement, fat quantification.

Interventions

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Liver MRI

Multiparametric Liver MRI including following sequences: DCE, DWI, MRE, precontrast flow measurement, fat quantification.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...)
* Or transplant recipient for viral hepatitis and on anti-viral agent medication
* AND scheduled for liver resection, biopsy or transient elastography
* AND signed informed consent

Exclusion Criteria

* younger than 18 years
* any contra-indication for contrast-enhanced MRI
* pregnant or nursing women
* biliary obstruction
* unable or unwilling to give informed consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No