Non-invasive Evaluation of Portal Pressure by MRI

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2019-07-31

Brief Summary

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The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.

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Detailed Description

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All patients will benefit from:

* Pressure gradient measurement portosystemic
* MRI measurement of azygos flow, aortic, portals, spleen and lower cellar
* Liver biopsy
* Laboratory tests

Conditions

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Chronic Liver Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Intervention

The measurement of portosystemic pressure gradient will be performed before liver biopsy.

Then liver biopsy is performed. The MRI was performed on the day of biopsy or within one week around the completion of the biopsy.

The MRI machine used is the Siemens 3T.

Group Type EXPERIMENTAL

Intervention

Intervention Type PROCEDURE

All patients performing the biopsy will have an MRI to carry out the necessary measures.

Interventions

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Intervention

All patients performing the biopsy will have an MRI to carry out the necessary measures.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Suspicion of chronic liver disease
* Indication to perform a liver biopsy transjugular
* Patient able to consent

Exclusion Criteria

* contraindication to MRI:
* Holders of a pacemaker or a defibrillator, an implanted material activated by electrical, magnetic or mechanical
* Holders of hemostatic clips intracerebral aneurysms or carotid arteries, bearing orthopedic implants
* claustrophobic
* Severe hepatic encephalopathy
* Inability to MRI in the week surrounding the first jugular

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No