Investigating the Effect of Yoga-based Breathing Styles on the Human Brain, With a Focus on Memory

NCT ID: NCT05846425

Last Updated: 2024-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-03

Study Completion Date

2024-12-31

Brief Summary

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The goal of this clinical trial is to learn if yoga-based breathing styles could improve memory performance in adult persons without relevant prior experience in yoga, meditation or similar disciplines and without existing health problems which could hinder the implementation of the breathing exercises.

The main questions it aims to answer are:

* Can the memory performance get better ?
* Can the subjective stress level be reduced ?

Participants will complete a memory test while doing a specific nasal and oral breathing.

They will complete a two-week training period after the test with daily nasal or mouth breathing training or no training at all, depending on the group, the are divided into.

Researchers will compare the effect of different breathing styles on memory ability among themselves.

Detailed Description

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The goal of this clinical trial is to learn about the effect of yoga-based breathing styles on the human brain regarding memory performance in adult persons without relevant prior experience in yoga, meditation or similar disciplines and without existing health problems which could hinder the performance of the breathing exercises.

The main questions it aims to answer are:

* Is there an improve of memory performance through performing the controlled yoga-based breathing styles ?
* Is there a relevant reduction of the subjective stress level through performing the controlled yoga-based breathing styles

Participants will complete a memory test while performing controlled nasal and oral breathing.

They will complete a two-week training period after the test with daily nasal or mouth breathing training or no training at all, depending on the group assignment.

Researchers will compare the nasal breathing group to the mouth breathing and the comparison group to see if the nasal breathing results in a significant improvement of the memory capacity.

Conditions

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Hypoventilation Hyperventilation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Nose-breathing group, Mouth-breathing group, Control group
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Nose-breathing

Controlled nose-breathing

Group Type EXPERIMENTAL

Nose-breathing training

Intervention Type OTHER

13 days of controlled nose-breathing training at a specific frequency with a duration of approximately 15 min a day

Mouth-breathing

Controlled mouth-breathing

Group Type ACTIVE_COMPARATOR

Mouth-breathing training

Intervention Type OTHER

13 days of controlled mouth-breathing training at a specific frequency with a duration of approximately 15 min a day

Control group

no intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Nose-breathing training

13 days of controlled nose-breathing training at a specific frequency with a duration of approximately 15 min a day

Intervention Type OTHER

Mouth-breathing training

13 days of controlled mouth-breathing training at a specific frequency with a duration of approximately 15 min a day

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Willingness to take on the 2-week exercises but no new athletic or meditative activities
* Yoga-naive and without significant prior experience in various meditative or athletic disciplines that ostensibly involve elements of breath control
* Access to a device with internet access
* Signing of the consent form to participate in the study

Exclusion Criteria

* Known clinically relevant internal or neurological diseases, especially if associated with chronic pathological oxygenation (e.g. COPD, severe bronchial asthma, sleep apnea, but also CKD).
* History of drug or alcohol abuse
* Known psychiatric illnesses that currently require therapy (e.g., pronounced claustrophobia)
* Medication that could falsify the data collected
* Lack of consent to take note of possible incidental findings
* known epileptic seizures, which could be intensified by the visual insertion of the stimuli
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universität des Saarlandes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christoph Krick, Dr.rer.med.

Role: PRINCIPAL_INVESTIGATOR

University of Saarland

Locations

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Department of Diagnostic and Interventional Neuroradiology, Saarland University Medical Center

Homburg, Saarland, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Maximilian A Becker

Role: CONTACT

+49 176 20205231

Facility Contacts

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Christoph M Krick, Dr.rer.med.

Role: primary

+49 6841 16 24359

Maximilian A Becker

Role: backup

+49 176 20205231

References

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Zelano C, Jiang H, Zhou G, Arora N, Schuele S, Rosenow J, Gottfried JA. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. J Neurosci. 2016 Dec 7;36(49):12448-12467. doi: 10.1523/JNEUROSCI.2586-16.2016.

Reference Type BACKGROUND
PMID: 27927961 (View on PubMed)

Klippenstein JL, Stark SM, Stark CEL, Bennett IJ. Neural substrates of mnemonic discrimination: A whole-brain fMRI investigation. Brain Behav. 2020 Mar;10(3):e01560. doi: 10.1002/brb3.1560. Epub 2020 Feb 3.

Reference Type BACKGROUND
PMID: 32017430 (View on PubMed)

Stark SM, Kirwan CB, Stark CEL. Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity. Trends Cogn Sci. 2019 Nov;23(11):938-951. doi: 10.1016/j.tics.2019.08.003. Epub 2019 Oct 6.

Reference Type BACKGROUND
PMID: 31597601 (View on PubMed)

Other Identifiers

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MST-Breathing Study

Identifier Type: -

Identifier Source: org_study_id

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