Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
NCT ID: NCT05804604
Last Updated: 2023-08-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2022-05-07
2022-11-29
Brief Summary
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• Is the higher concentration of bone intake proteins and muscle atrophy marker a predictive factor of proximal femur fracture?
The part of participants (Group 1) will be hospitalized at the Department of Orthopaedics and Rehabilitation and will undergo a surgical treatment (open reduction of the fracture). The rest (Group 2) will be admitted to the Department of Internal Medicine. Participants of both Groups will have the blood sample test taken, to evaluate and compare the serum concentration of SHBG, CTX-I and CK-MB proteins.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Level of bone intake proteins and muscle atrophy marker in patients after proximal femur fracture
Open reduction of femoral neck or pertrochanteric fracture and preoperative analysis of bone intake proteins and muscle atrophy marker serum concentration
Surgical treatment of proximal femur fracture and blood sample test
Open reduction of femoral neck or pertrochanteric fracture with hemi/total hip arthroplasty or gamma nail. Analysis of serum concentration of: SHBG, CTX - I, CK-MB
Level of bone intake proteins and muscle atrophy marker in patients without proximal femur fracture
Control group without a history of proximal femur fracture. Analysis of the bone intake proteins and muscle atrophy marker serum level
Blood sample test
Analysis of serum concentration of: SHBG, CTX - I, CK-MB
Interventions
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Surgical treatment of proximal femur fracture and blood sample test
Open reduction of femoral neck or pertrochanteric fracture with hemi/total hip arthroplasty or gamma nail. Analysis of serum concentration of: SHBG, CTX - I, CK-MB
Blood sample test
Analysis of serum concentration of: SHBG, CTX - I, CK-MB
Eligibility Criteria
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Inclusion Criteria
* Proximal femur fracture (Group 1)
Exclusion Criteria
* prevalent fracture
* mental illness
* immune disease affecting protein balance
65 Years
ALL
Yes
Sponsors
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Medical University of Warsaw
OTHER
Responsible Party
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Artur Stolarczyk
Professor
Locations
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Department of Othopedics and Rehabilitation, Medical University of Warsaw
Warsaw, , Poland
Countries
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Other Identifiers
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WarsawMU/FOPF
Identifier Type: -
Identifier Source: org_study_id
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