Growth Parameters & Body Mass Index in Children With Chronic Diseases

NCT ID: NCT05801718

Last Updated: 2023-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-01

Study Completion Date

2024-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Deviations from the normal pattern of growth may be the first clues to pathology as in many chronic diseases evaluated clinically by anthropometric measurements \& body mass index. Growth impairment in children with chronic diseases is associated with disruption of the growth hormone (GH) and predominantly results from undernutrition, chronic inflammation and prolonged corticosteroid treatment.

Undernutrition leads to major adaptations in the endocrine system towards conserving energy, diverting substrates away from growth and reproduction, and providing alternative sources of energy for critical body homeostasis. chronic inflammatory processes exacerbate undernutrition through proinflammatory cytokines such as interleukin-1\&6 and tumor necrosis factor. These growth-regulating mechanisms are disturbed further by corticosteroids used in some chronic conditions for their anti-inflammatory and immunosuppressive properties.

Growth impairment occurs with many chronic conditions e g: Congenital heart dieases (CHD), chronic pulmonary diseases such as bronchial asthma, Gastrointestinal diseases sch as inflammatory bowel disease ,Chronic liver diseases , Chronic renal diseases, Chronic hemolytic anemia and chronic Central nervous system diseases.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Medical Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

chronic cardiac patients

patients with chronic cardiac diseases affecting their groth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic renal patients

patients with chronic renal diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic respiratory diseases

patients with chronic respiratory diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic metabolic diseases

patients with chronic metabolic diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic neurological diseases

patients with chronic neurological diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic haematological diseases

patients with chronic haematological diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

chronic gastro-intestinal diseases

patients with chronic gastro-intestinal diseases affecting their growth parameters \& body mass index

Growth parameters & body mass index

Intervention Type DIAGNOSTIC_TEST

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Growth parameters & body mass index

measuring the anthropometric measurements including: Weight, height/ length, head circumference, mid arm circumference\& skin fold thickness and measuring body mass index.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age: under 12 years old.
* Both sex .
* Patients with chronic medical diseases.

Exclusion Criteria

* Age: over 12years old.
* Patients with acute diseases.
* Pediatric with malignancy.
* chronic patients with surgical sequelae.
Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Sohag University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Norhan Nabil Ahmed

resident at pediatric department at Sohag university hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Sohag University Hospital

Sohag, , Egypt

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

norhan n ahmed, resident

Role: CONTACT

01021556144

mohamed a mohamed, professor

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

magdy m ameen, professor

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Costello CL, Gellatly M, Daniel J, Justo RN, Weir K. Growth Restriction in Infants and Young Children with Congenital Heart Disease. Congenit Heart Dis. 2015 Sep-Oct;10(5):447-56. doi: 10.1111/chd.12231. Epub 2014 Nov 11.

Reference Type BACKGROUND
PMID: 25385245 (View on PubMed)

Rodig NM, McDermott KC, Schneider MF, Hotchkiss HM, Yadin O, Seikaly MG, Furth SL, Warady BA. Growth in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study. Pediatr Nephrol. 2014 Oct;29(10):1987-95. doi: 10.1007/s00467-014-2812-9. Epub 2014 Apr 12.

Reference Type BACKGROUND
PMID: 24728472 (View on PubMed)

Amaro F, Chiarelli F. Growth and Puberty in Children with Inflammatory Bowel Diseases. Biomedicines. 2020 Oct 29;8(11):458. doi: 10.3390/biomedicines8110458.

Reference Type BACKGROUND
PMID: 33138015 (View on PubMed)

Hauspie R, Susanne C, Alexander F. Maturational delay and temporal growth retardation in asthmatic boys. J Allergy Clin Immunol. 1977 Mar;59(3):200-6. doi: 10.1016/0091-6749(77)90150-6.

Reference Type BACKGROUND
PMID: 190283 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Soh-Med-23-03-09MS

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.