Ultrasound Markers of Systemic Inflammation

NCT ID: NCT05798182

Last Updated: 2023-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

61 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2021-12-30

Brief Summary

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The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.

Detailed Description

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The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel \[dB\] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.

Conditions

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Inflammation Process Endothelial Dysfunction Vasomotor Arterial Disorder Vascular Dilation Swelling; Hand

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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ICU patients

Adult patients admitted to the ICU.

Ultrasound measurement

Intervention Type DIAGNOSTIC_TEST

Study was conducted with Mindray T7 ultrasound machine using linear probe. Vascular ultrasound mode was used with settings depth of 50 mm and gain of 40 dB during the entire study period. The diameter and flow velocity of the brachial artery and wrist edema of the fist were measured within 24 hours of admission and the following day.

Interventions

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Ultrasound measurement

Study was conducted with Mindray T7 ultrasound machine using linear probe. Vascular ultrasound mode was used with settings depth of 50 mm and gain of 40 dB during the entire study period. The diameter and flow velocity of the brachial artery and wrist edema of the fist were measured within 24 hours of admission and the following day.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Mindray T7 ultrasound machine

Eligibility Criteria

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Inclusion Criteria

* Adults over 18 years of age
* Postoperative surgical patients
* Signed informed consent

Exclusion Criteria

* Refusal to give informed consent
* A previous thromboembolic event of the brachial artery
* Acute infection of the upper extremity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Josip Juraj Strossmayer University of Osijek

OTHER

Sponsor Role collaborator

Osijek University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Slavica Kvolik, M.D., PhD,

Role: STUDY_DIRECTOR

Osijek University Hospital

Locations

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Slavica Kvolik

Osijek, , Croatia

Site Status

Countries

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Croatia

References

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Chakraborty RK, Burns B. Systemic Inflammatory Response Syndrome. [Updated 2021 Jul 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547669/

Reference Type BACKGROUND

Čavka A, Tadžić R, Grizelj I, Unfirer S, Mihaljević Z, Mihalj M et al. Endotelna funkcija - funkcionalni pokazatelj kardiovaskularnih rizičnih čimbenika. Medicinski vjesnik [Internet]. 2012 [Accessed 23.05.2021.];44((1-4)):135-146. Available from: https://hrcak.srce.hr/187756

Reference Type BACKGROUND

Lu D, Kassab GS. Role of shear stress and stretch in vascular mechanobiology. J R Soc Interface. 2011 Oct 7;8(63):1379-85. doi: 10.1098/rsif.2011.0177. Epub 2011 Jul 6.

Reference Type BACKGROUND
PMID: 21733876 (View on PubMed)

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23.

Reference Type BACKGROUND
PMID: 29467962 (View on PubMed)

Mortaz E, Alipoor SD, Adcock IM, Mumby S, Koenderman L. Update on Neutrophil Function in Severe Inflammation. Front Immunol. 2018 Oct 2;9:2171. doi: 10.3389/fimmu.2018.02171. eCollection 2018.

Reference Type BACKGROUND
PMID: 30356867 (View on PubMed)

Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018 Apr 13;9:754. doi: 10.3389/fimmu.2018.00754. eCollection 2018.

Reference Type BACKGROUND
PMID: 29706967 (View on PubMed)

Evans DH. Colour flow and motion imaging. Proc Inst Mech Eng H. 2010;224(2):241-53. doi: 10.1243/09544119JEIM599.

Reference Type BACKGROUND
PMID: 20349817 (View on PubMed)

Kubler A, Maciejewski D, Adamik B, Kaczorowska M. Mechanical ventilation in ICUs in Poland: a multi-center point-prevalence study. Med Sci Monit. 2013 Jun 3;19:424-9. doi: 10.12659/MSM.883930.

Reference Type BACKGROUND
PMID: 23727991 (View on PubMed)

Other Identifiers

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2158-61-07-21-96

Identifier Type: -

Identifier Source: org_study_id

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