Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light
NCT ID: NCT05793437
Last Updated: 2024-02-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
84 participants
INTERVENTIONAL
2023-04-01
2024-01-28
Brief Summary
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Detailed Description
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Secondary endpoints:CAM (Confusion Assessment Method) is conducted to check the subjects' baseline cognitive function preoperative day and 1 day postoperatively to assess whether delirium occurs.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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permissive hypercapnia
Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg
permissive hypercapnia
Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg
normocapnia
Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg
normocapnia
Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg
Interventions
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permissive hypercapnia
Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg
normocapnia
Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* duration of pneumoperitoneum greater than 60 minutes
* American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ
* undergoing laparoscopic surgery under general anesthesia with endotracheal intubation
Exclusion Criteria
* preoperative use of antipsychotic drugs
* American Society of Anesthesiology (ASA) status Ⅳ
* severe abnormalities in heart, lung, liver, kidney, and coagulation function
* Intracranial space-occupying lesions or major cerebrovascular diseases (such as carotid atherosclerosis and cerebral aneurysm)
* Severe hypertension or hypotension
* Severe metabolic acidosis or hypercapnic respiratory failure before surgery
60 Years
ALL
No
Sponsors
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Affiliated Hospital of Jiaxing University
OTHER
Responsible Party
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Qing-he Zhou
Principal investigator
Principal Investigators
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Qinghe Zhou
Role: PRINCIPAL_INVESTIGATOR
Affiliated Hospital of Jiaxing University
Locations
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Affiliated Hospital of Jiaxing University
Jiaxing, Zhejiang, China
Countries
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Other Identifiers
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2023-KY-050
Identifier Type: -
Identifier Source: org_study_id
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