The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Chronic Low Back Pain

NCT ID: NCT05779748

Last Updated: 2025-08-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-15
• Study Completion Date: 2023-08-05

Brief Summary

The goal of this interventional study is to investigate the efficacy of an acute bout of exercises on pain sensitivity (primary aim) and clinical pain intensity (secondary aim) among adults with Chronic Low Back Pain. The following question will be answered in this research Q1: Is acute bout of exercise effective in reducing pain among adults with Chronic Low Back Pain?

Participants who agree to participate and sign the informed consent will be randomized to one of three groups:

Group 1: Isometric exercise with neutral language and no verbal suggestion consisting of 1 rep of wall squat, 3 min or to volitional fatigue at 100° knee angle;(n=30).

Group 2: Isometric exercise with neutral language and no verbal suggestion consisting of 3 reps of wall squat, 3 min or to volitional fatigue at 100°degree knee angle, 30-sec rest between rep, ;(n=30).

Group 3 (Control group): true control (do nothing);(n=30).

Conditions

Chronic Low-back Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Isometric exercise-one repetition

Isometric exercise consisting of 1 session only. The session will last for around 5 minutes which will include asking the patient to do 1 repetition of wall squat for 3 min or to volitional fatigue at 100° knee angle.

Intervention: Other: Single bout of exercise

Group Type: EXPERIMENTAL

Single bout of exercise

Intervention Type: OTHER

isometric wall squat at a knee joint angle of 100 degrees. Instruct participant to place their back against the wall with feet positioned parallel and spaced shoulder-width apart. Lower themselves down until they reached a knee joint angle of 100 degrees. Measure knee joint angle by placing a goniometer on the lateral epicondyle of the knee, in line with the femur whilst the anchor arm was in line with the lateral malleolus.

Isometric exercise-three repetitions

isometric exercise consisting of 1 session only. The session will last for around 10 minutes which will include asking the patient to perform 3 repetitions of wall squats (each time the exercise will be performed for 3 min or to volitional fatigue at 100°degree knee angle); the patient will be given 30-sec rest between repetitions.

Intervention: Other: Single bout of exercise

Group Type: EXPERIMENTAL

Single bout of exercise

Intervention Type: OTHER

isometric wall squat at a knee joint angle of 100 degrees. Instruct participant to place their back against the wall with feet positioned parallel and spaced shoulder-width apart. Lower themselves down until they reached a knee joint angle of 100 degrees. Measure knee joint angle by placing a goniometer on the lateral epicondyle of the knee, in line with the femur whilst the anchor arm was in line with the lateral malleolus.

Control

Will not receive any intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Single bout of exercise

isometric wall squat at a knee joint angle of 100 degrees. Instruct participant to place their back against the wall with feet positioned parallel and spaced shoulder-width apart. Lower themselves down until they reached a knee joint angle of 100 degrees. Measure knee joint angle by placing a goniometer on the lateral epicondyle of the knee, in line with the femur whilst the anchor arm was in line with the lateral malleolus.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. aged 18 years or older; and

2. diagnosed with chronic non-specific LBP (lasting for more than 12 weeks).

3. Able to perform physical therapy exercises.

Exclusion Criteria

1. pregnancy.

2. patients who have neurological compromise (e.g., cauda equine syndrome or spinal nerve compromise).

3. Patients who have spinal pathologies (e.g., fracture, ankylosing spondylitis)

4. Uncontrolled diabetic.

5. who has any history of heart disease (e.g., myocardial infarction, embolism)

6. Orthopaedic impairment (e.g., balance problems)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

King Abdullah Hospital

UNKNOWN

Sponsor Role: collaborator

Taif University

OTHER

Sponsor Role: lead

Responsible Party

Hosam Alzahrani

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hossam Alzahrani, PhD

Role: PRINCIPAL_INVESTIGATOR

Taif University

Locations

King Abdullah Hospital

Bisha, , Saudi Arabia

Countries

Saudi Arabia

Other Identifiers

BIS-23-00007-11012023

Identifier Type: -

Identifier Source: org_study_id