Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Axicabtagene Ciloleucel

NCT ID: NCT05776160

Last Updated: 2025-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

AVAILABLE

Study Classification

EXPANDED_ACCESS

Brief Summary

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The goal of this study is to provide access to axicabtagene ciloleucel for patients diagnosed with a disease approved for treatment with axicabtagene ciloleucel, that is otherwise out of specification for commercial release.

Detailed Description

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Conditions

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Large B-cell Lymphoma Follicular Lymphoma

Interventions

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Axicabtagene Ciloleucel

A single infusion of chimeric antigen receptor (CAR)-transduced autologous T cells/kg administered intravenously.

Intervention Type DRUG

Other Intervention Names

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Yescarta®

Eligibility Criteria

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Inclusion Criteria

* Have commercially manufactured axicabtagene ciloleucel that does not meet commercial release criteria but does meet Kite clinical trial release criteria
* Females of childbearing potential must have a negative serum or urine pregnancy test (females who have undergone surgical sterilization or who have been post-menopausal for at least 2 years are not considered to be of childbearing potential)
* Deemed medically fit and stable to receive the product per the investigator's evaluation
* Repeat leukapheresis is not feasible per the investigator's assessment
* Be diagnosed with 1 of the approved labeled indications for axicabtagene ciloleucel that is intended for release
* In the investigator's opinion, there is no satisfactory alternative therapy available to the individual

Exclusion Criteria

* History of severe immediate hypersensitivity to any drugs or metabolites of similar chemical classes as axicabtagene ciloleucel
* Uncontrolled active infection or inflammation per physician assessment
* Primary central nervous system lymphoma
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kite, A Gilead Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kite Study Director

Role: STUDY_DIRECTOR

Kite, A Gilead Company

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status AVAILABLE

Banner MD Anderson Cancer Center

Gilbert, Arizona, United States

Site Status AVAILABLE

City of Hope Medical Center

Duarte, California, United States

Site Status AVAILABLE

Colorado Blood Cancer Institute

Denver, Colorado, United States

Site Status AVAILABLE

Mayo Clinic Florida

Jacksonville, Florida, United States

Site Status AVAILABLE

Moffitt Cancer Center

Tampa, Florida, United States

Site Status AVAILABLE

Winship Cancer Institute

Atlanta, Georgia, United States

Site Status AVAILABLE

Northside Hospital

Atlanta, Georgia, United States

Site Status AVAILABLE

St. Luke's Cancer Institute

Boise, Idaho, United States

Site Status AVAILABLE

Northwestern Memorial Hospital

Chicago, Illinois, United States

Site Status AVAILABLE

The University of Kansas Medical Center

Westwood, Kansas, United States

Site Status AVAILABLE

University of Maryland Cancer Center

Baltimore, Maryland, United States

Site Status AVAILABLE

Johns Hopkins Hospital

Baltimore, Maryland, United States

Site Status AVAILABLE

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status AVAILABLE

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status AVAILABLE

Dana Farber Cancer Institute - Chestnut Hill

Boston, Massachusetts, United States

Site Status AVAILABLE

University of Michigan

Ann Arbor, Michigan, United States

Site Status AVAILABLE

Mayo Clinic

Rochester, Minnesota, United States

Site Status AVAILABLE

Washington University School of Medicine- Siteman Cancer Center

St Louis, Missouri, United States

Site Status AVAILABLE

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status AVAILABLE

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status AVAILABLE

Roswell Park Cancer Institute

Buffalo, New York, United States

Site Status AVAILABLE

Weill Cornell Medicine - NewYork-Presbyterian Hospital

New York, New York, United States

Site Status AVAILABLE

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status AVAILABLE

University of Rochester Medical Center

Rochester, New York, United States

Site Status AVAILABLE

Montefiore Medical Center (MMC)

The Bronx, New York, United States

Site Status AVAILABLE

UNC Hospitals, The University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status AVAILABLE

Cleveland Clinic

Cleveland, Ohio, United States

Site Status AVAILABLE

The Ohio State University Wexner Medical Center- James Cancer Hospital

Columbus, Ohio, United States

Site Status AVAILABLE

Oregon Health & Science University

Portland, Oregon, United States

Site Status AVAILABLE

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status AVAILABLE

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Site Status AVAILABLE

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

Site Status AVAILABLE

Avera Cancer Institute

Sioux Falls, South Dakota, United States

Site Status AVAILABLE

Sarah Cannon Research Institute

Nashville, Tennessee, United States

Site Status AVAILABLE

Tennessee Oncology

Nashville, Tennessee, United States

Site Status AVAILABLE

Vanderbilt-Ingrim Cancer Center

Nashville, Tennessee, United States

Site Status AVAILABLE

Baylor University Medical Center

Dallas, Texas, United States

Site Status AVAILABLE

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status AVAILABLE

Houston Methodist Hospital

Houston, Texas, United States

Site Status AVAILABLE

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Site Status AVAILABLE

Methodist Healthcare System of San Antonio dba Methodist Hospital

San Antonio, Texas, United States

Site Status AVAILABLE

Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, United States

Site Status AVAILABLE

University of Virginia Comprehensive Cancer Center

Charlottesville, Virginia, United States

Site Status AVAILABLE

Virginia Commonwealth University

Richmond, Virginia, United States

Site Status AVAILABLE

Fred Hutchinson Cancer Center

Seattle, Washington, United States

Site Status AVAILABLE

West Virginia University

Morgantown, West Virginia, United States

Site Status AVAILABLE

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status AVAILABLE

Anjo Kosei Hospital

Aichi, , Japan

Site Status AVAILABLE

Nagoya Medical Center

Aichi, , Japan

Site Status AVAILABLE

Nagoya City University Hospital

Aichi, , Japan

Site Status AVAILABLE

Aichi Medical University Hospital

Aichi, , Japan

Site Status AVAILABLE

Akita University Hospital

Akita, , Japan

Site Status AVAILABLE

Chiba University Hospital

Chiba, , Japan

Site Status AVAILABLE

Ehime University Hospital

Ehime, , Japan

Site Status AVAILABLE

University of Fukui Hospital

Fukui, , Japan

Site Status AVAILABLE

Kokura Kinen Hospital

Fukuoka, , Japan

Site Status AVAILABLE

Hamanomachi Hospital

Fukuoka, , Japan

Site Status AVAILABLE

Kyushu Medical Center

Fukuoka, , Japan

Site Status AVAILABLE

Kyushu University Hospital

Fukuoka, , Japan

Site Status AVAILABLE

Kurume University Hospital

Fukuoka, , Japan

Site Status AVAILABLE

Gifu Municipal Hospital

Gifu, , Japan

Site Status AVAILABLE

Gunma University Hospital

Gunma, , Japan

Site Status AVAILABLE

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, , Japan

Site Status AVAILABLE

Hiroshima University Hospital

Hiroshima, , Japan

Site Status AVAILABLE

Sapporo Hokuyu Hospital

Hokkaido, , Japan

Site Status AVAILABLE

Hokkaido University Hospital

Hokkaido, , Japan

Site Status AVAILABLE

Kobe University Hospital

Hyōgo, , Japan

Site Status AVAILABLE

Kobe City Medical Center General Hospital

Hyōgo, , Japan

Site Status AVAILABLE

Hyogo Medical University Hospital

Hyōgo, , Japan

Site Status AVAILABLE

University of Tsukuba Hospital

Ibaraki, , Japan

Site Status AVAILABLE

Kagawa University Hospital

Kagawa, , Japan

Site Status AVAILABLE

Kagoshima University Hospital

Kagoshima, , Japan

Site Status AVAILABLE

Yokohama City University Medical Center

Kanagawa, , Japan

Site Status AVAILABLE

Yokohama City University Hospital

Kanagawa, , Japan

Site Status AVAILABLE

Kanazawa University Hospital

Kanazawa, , Japan

Site Status AVAILABLE

Kumamoto University Hospital

Kumamoto, , Japan

Site Status AVAILABLE

University Hospital Kyoto Prefectural University of Medicine

Kyoto, , Japan

Site Status AVAILABLE

Japanese Red Cross Kyoto Daiichi Hospital

Kyoto, , Japan

Site Status AVAILABLE

Kyoto University Hospital

Kyoto, , Japan

Site Status AVAILABLE

Mie University Hospital

Mie, , Japan

Site Status AVAILABLE

Tohoku University Hospital

Miyagi, , Japan

Site Status AVAILABLE

University of Miyazaki Hospital

Miyazaki, , Japan

Site Status AVAILABLE

Shinshu University Hospital

Nagano, , Japan

Site Status AVAILABLE

Nagasaki University Hospital

Nagasaki, , Japan

Site Status AVAILABLE

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital

Nagoya, , Japan

Site Status AVAILABLE

Nagoya University Hospital

Nagoya, , Japan

Site Status AVAILABLE

Niigata University Medical & Dental Hospital

Niigata, , Japan

Site Status AVAILABLE

Okayama University Hospital

Okayama, , Japan

Site Status AVAILABLE

Kurashiki Central Hospital

Okayama, , Japan

Site Status AVAILABLE

Univercity of the Ryukyus Hospital

Okinawa, , Japan

Site Status AVAILABLE

Osaka International Cancer Institute

Osaka, , Japan

Site Status AVAILABLE

Osaka Red Cross Hospital

Osaka, , Japan

Site Status AVAILABLE

Osaka Metropolitan University Hospital

Osaka, , Japan

Site Status AVAILABLE

The University of Osaka Hospital

Osaka, , Japan

Site Status AVAILABLE

Kansai Medical University Hospital

Osaka, , Japan

Site Status AVAILABLE

Kindai University Hospital

Osaka, , Japan

Site Status AVAILABLE

Oita University Hospital

Ōita, , Japan

Site Status AVAILABLE

Jichi Medical University Saitama Medical Center

Saitama, , Japan

Site Status AVAILABLE

Saitama Medical Center

Saitama, , Japan

Site Status AVAILABLE

Shiga University of Medical Science Hospital

Shiga, , Japan

Site Status AVAILABLE

Shimane University Hospital

Shimane, , Japan

Site Status AVAILABLE

Hamamatsu University Hospital

Shizuoka, , Japan

Site Status AVAILABLE

Jichi Medical University Hospital

Tochigi, , Japan

Site Status AVAILABLE

Tokushima University Hospital

Tokushima, , Japan

Site Status AVAILABLE

National Cancer Center Hospital

Tokyo, , Japan

Site Status AVAILABLE

Toranomon Hospital

Tokyo, , Japan

Site Status AVAILABLE

Jikei University Hospital

Tokyo, , Japan

Site Status AVAILABLE

Juntendo University School of Medicine Juntendo Clinic

Tokyo, , Japan

Site Status AVAILABLE

Institute of Science Tokyo Hospital

Tokyo, , Japan

Site Status AVAILABLE

The University of Tokyo Hospital

Tokyo, , Japan

Site Status AVAILABLE

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital

Tokyo, , Japan

Site Status AVAILABLE

Keio University Hospital

Tokyo, , Japan

Site Status AVAILABLE

Teikyo University Hospital

Tokyo, , Japan

Site Status AVAILABLE

Nihon University Itabashi Hospital

Tokyo, , Japan

Site Status AVAILABLE

Tokyo Metropolitan Tama Medical Center

Tokyo, , Japan

Site Status AVAILABLE

Tottori Univeristy Hospital

Tottori, , Japan

Site Status AVAILABLE

Toyama Prefectural Central Hospital

Toyama, , Japan

Site Status AVAILABLE

Wakayama Medical University Hospital

Wakayama, , Japan

Site Status AVAILABLE

Yamagata University Hospital

Yamagata, , Japan

Site Status AVAILABLE

Yamaguchi University Hospital

Yamaguchi, , Japan

Site Status AVAILABLE

Countries

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United States Japan

Central Contacts

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Medical Information

Role: CONTACT

844-454-5483(1-844-454-KITE)

Related Links

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Other Identifiers

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KT-US-471-0140

Identifier Type: -

Identifier Source: org_study_id

jRCT2033230370

Identifier Type: OTHER

Identifier Source: secondary_id

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