Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2022-08-22
2023-01-10
Brief Summary
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The present study 'Application of Extracorporeal Shock Wave Therapy on human gingival derived fibroblasts In-vitro study' was done to explore and evaluate the effect of shockwaves. Further, these cells were assessed for Cell - Cell interaction and Cell Viability.
In this in-vitro study, 20 fibroblast cells were included. 10 samples were considered for Control group and the remaining 10 samples were considered as Test group. Extracorporeal shockwave was applied to the Test samples. They were further analysed
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Detailed Description
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Improved understanding of human biology at the molecular level, scientific and technologic advances are emerging aspects in dentistry. The idea of treating different deformities or diseases in the maxillofacial region with Extracorporeal Shockwave Therapy (ESWT) has recently become popular. Shockwave therapy was first introduced in Germany in 1980s and has been widely used in medical practice for the management of urolithiasis, cholelithiasis and in head and neck region for sialolithiasis.
AIM:
The present study 'Application of Extracorporeal Shock Wave Therapy on human gingival tissue derived fibroblasts In-vitro study' was done to explore and evaluate the effect of shockwaves. Further, fibroblast cells were assessed for Cell - Cell interaction and Cell Viability.
MATERIALS AND METHODS:
In this in-vitro study, 20 fibroblast cells were included. 10 samples were considered for Control group and the remaining 10 samples were considered as Test group. Extracorporeal shockwave was applied to the Test samples. They were further analysed using wound scratch assay which was used to assess Cell proliferative rate and scratch closure through live imaging. MTT assay and ATP assay was used to determine Cell viability after exposure to shockwaves.
Conditions
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Study Design
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NON_RANDOMIZED
SEQUENTIAL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Shockwave treated group
Effect of Extracorporeal shockwaves on Fibroblast cell proliferation and cell viability
extracorporeal shockwave device
Fibroblast cell lines (n=10) were subjected to Shockwaves from extracorporeal shockwave device
No shockwave group
Fibroblast cell lines assessed for proliferative rate and viability without shockwave exposure.
Fibroblast cell lines not subjected to shockwaves from extracorporeal shockwave device
Fibroblast cell lines (n=10) without shockwave exposure
Interventions
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extracorporeal shockwave device
Fibroblast cell lines (n=10) were subjected to Shockwaves from extracorporeal shockwave device
Fibroblast cell lines not subjected to shockwaves from extracorporeal shockwave device
Fibroblast cell lines (n=10) without shockwave exposure
Eligibility Criteria
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Inclusion Criteria
* Healthy gingival tissue
Exclusion Criteria
ALL
No
Sponsors
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Dr Prabhuji MLV
OTHER
Responsible Party
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Dr Prabhuji MLV
Professor, Head of Periodontology, Principle investigator, Clinical Professor
Locations
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Krishnadevaraya College of Dental Science and Hospital
Bengaluru, Karnataka, India
Countries
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Other Identifiers
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KCDS/48
Identifier Type: -
Identifier Source: org_study_id
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