The Use of Leucocyte Platelet Rich Fibrin (L- PRF) Covered Perforated Guided Tissue Membrane for Treatment of Periodontal Intrabony Defects
NCT ID: NCT04576468
Last Updated: 2020-10-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2018-06-01
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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open flap debridement
envelope full thickness flap reflection, removal of granulation tissue then suturing with simple loop sutures.
Open flap debridement
Surgical intevention
perforated membrane (PM)
envelope full thickness flap reflection, removal of granulation tissue placing resorbable membrane after perforating it over the vertical defect then suturing with simple loop sutures.
Open flap debridement
Surgical intevention
perforated membrane
surgical intervention
leucocyte platelet rich fibrin (L-PRF)
envelope full thickness flap reflection, removal of granulation tissue after withdrawal of blood and placing it in intraspin centrifuge , placing the resulting L-PRF in the defect then suturing with simple loop sutures.
Open flap debridement
Surgical intevention
leucocyte - platelet rich fibrin
surgical intervention
L-PRF + PM
envelope full thickness flap reflection, removal of granulation tissue after withdrawal of blood and placing it in intraspin centrifuge , placing the resulting L-PRF covered by resorbable membrane after perforating it in the defect then suturing with simple loop sutures.
Open flap debridement
Surgical intevention
perforated membrane
surgical intervention
leucocyte - platelet rich fibrin
surgical intervention
Interventions
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Open flap debridement
Surgical intevention
perforated membrane
surgical intervention
leucocyte - platelet rich fibrin
surgical intervention
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients free from any systemic diseases that may contra-indicate periodontal surgery (Ahmed Y. Gamal et al., 2014).
* Two- or three-wall intrabony defects in premolar/molar teeth without furcation involvement, that are measured from the alveolar crest to the defect bottom in diagnostic periapical radiographs of ≥ 3 mm (Reynolds et al., 2015).
* Probing depth ≥ 5 mm and clinical attachment loss ≥ 4 mm at the site of intrabony defects 4 week after the phase one therapy (Ahmed Y. Gamal et al., 2014).
* Free from any periapical pathosis.
* Patients willing and able to return for multiple follow up visits and perform oral hygiene instructions.
* Absence of occlusal interference, mobility and open interproximal contact.
* Good fulfillment to plaque control instructions following initial therapy.
Exclusion Criteria
* Pregnant and breast feeding females.
* Periodontal surgical treatment in the previous 12 months at the involved sites. (A. Y. Gamal et al., 2016)
* Persistence of gingival inflammation after phase I therapy.
* Vulnerable groups as handicapped, mentally disabled, prisoners and orphans.
18 Years
60 Years
ALL
Yes
Sponsors
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Future University in Egypt
OTHER
Ain Shams University
OTHER
Responsible Party
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Mariam Samir
principal investigator
Principal Investigators
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Ahmed Y Gamal, Professor
Role: STUDY_DIRECTOR
Faculty of dentistry - Ain shams University
Locations
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Faculty of dentistry Ain shams University
Cairo, , Egypt
Countries
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Other Identifiers
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FDAS-RecIM011735
Identifier Type: -
Identifier Source: org_study_id
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