Wastewater Surveillance to Boost COVID-19 Vaccine Uptake

NCT ID: NCT05766189

Last Updated: 2026-01-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 100000 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-01
• Study Completion Date: 2025-12-31

Brief Summary

The goal of the study is to determine the effect of a communications campaign sharing wastewater surveillance data to influence vaccine uptake in a metropolitan and non-metropolitan environment. The study will be conducted in Onondaga and Cayuga counties in New York State. Individuals of all ages within the selected counties, located in metropolitan and non-metropolitan environments will receive the intervention. The evaluation study design is a comparison-control trial. The primary outcome measure is the proportion of vaccine-eligible individuals in the county that received the COVID-19 vaccine stratified by type of vaccine dosage and age group. Vaccination data will be aggregated to the county by the State Department of Health and shared with the research team. Wastewater data will be pulled from the wastewater surveillance network. A difference in differences analysis will be used to estimate the effect of the intervention on both the outcomes between intervention and comparison groups following the intervention, while adjusting for potential confounding factors.

Conditions

Vaccination; Wastewater Surveillance

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Intervention arm

Receives communications on level of SARS-CoV-2 as identified in the wastewater

Group Type: EXPERIMENTAL

Wastewater vaccine prompts

Intervention Type: BEHAVIORAL

Social media communications showing levels of SARS-CoV-2 in wastewater

Comparison arm

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Wastewater vaccine prompts

Social media communications showing levels of SARS-CoV-2 in wastewater

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• None - county-level vaccine uptake - no direct interaction with people getting vaccines

Exclusion Criteria

• None

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Syracuse University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Syracuse University

Syracuse, New York, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

BOOST-wastewater

Identifier Type: -

Identifier Source: org_study_id