Satiety of High-Protein Ramen Noodles

NCT ID: NCT05725681

Last Updated: 2025-04-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-06-01
• Study Completion Date: 2023-12-02

Brief Summary

The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles.

Detailed Description

The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles. Subjects meeting the eligibility criteria will be recruited and offered a 2-condition, randomized, crossover postprandial study. Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, in random order, participants will consume: 1) one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods); 2) an isocaloric, weight matched portion of standard instant ramen noodles. The participants will have to finish consuming the noodles within 15 minutes. Water will be provided at the time of breakfast and for the next two hours. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. Subjects will leave the clinic at this point. The process will be repeated for the second condition after at least 7 d washout period.

Conditions

Appetitive Behavior

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: TRIPLE

Study Groups

High protein ramen

Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods). In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed.

Group Type: EXPERIMENTAL

High protein ramen

Intervention Type: OTHER

Participants will be served one portion of high-protein instant ramen noodles \[CHEF WOO Roasted Chicken Flavor Ramen Cup Noodles, Borealis Foods; 71 g\]

Standard ramen

Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume an isocaloric, weight matched portion of standard instant ramen noodles. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed.

Group Type: ACTIVE_COMPARATOR

Standard ramen

Intervention Type: OTHER

Participants will be served one portion of standard instant ramen noodles \[RAMEN EXPRESS Chicken Flavor Ramen Cup Noodle Chef Woo, Borealis Foods; 71 g\]

Interventions

High protein ramen

Participants will be served one portion of high-protein instant ramen noodles \[CHEF WOO Roasted Chicken Flavor Ramen Cup Noodles, Borealis Foods; 71 g\]

Intervention Type: OTHER

Standard ramen

Participants will be served one portion of standard instant ramen noodles \[RAMEN EXPRESS Chicken Flavor Ramen Cup Noodle Chef Woo, Borealis Foods; 71 g\]

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Body Mass Index 20-30 kg/m2

Exclusion Criteria

• Unwilling or unable to have an IV catheter inserted
• Body weight <110 pounds
• Diabetes (any type)
• Fasting capillary glucose ≥100 mg/dL
• Unstable systemic medical condition

•>10% change in body weight in the prior 3 months

• Medications that affect appetite or glucose regulation
• Prior bariatric surgery
• Uncontrolled hypertension (i.e., unmedicated blood pressure >130/90 mmHg)
• Intolerance, dislike or allergy to the study food
• Current or recent (within 6 months) tobacco use
• High alcohol consumption (>14 drinks/week)
• Currently following a weight loss diet
• Irregular menstrual cycle
• Currently pregnant or lactating
• Principal investigator discretion (e.g., disrespectful or inappropriate interactions with study staff

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Texas Tech University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nikhil Dhurandhar

Role: PRINCIPAL_INVESTIGATOR

Department of Nutritional Sciences Texas Tech University

Kristina Petersen

Role: PRINCIPAL_INVESTIGATOR

Department of Nutritional Sciences Texas Tech University

Locations

Nutrition and Metabolic Health Initiative

Lubbock, Texas, United States

Countries

United States

Other Identifiers

22-0729

Identifier Type: -

Identifier Source: org_study_id