Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-15

Study Completion Date

2023-06-19

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will be conducted to evaluate the effect of intraoperative systemic aminophylline infusion on pain intensity in patients undergoing ureteroscopic lithotripsy surgeries with ureteric stent placement at the end of the procedure.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure

NCT06830577

Stones, Kidney Ureteric Injury

RECRUITING NA

Efficacy of Intra-Ureteric Aminophylline Installation After Failed Stone Accessibility by Semi-rigid Ureteroscopy. Prospective Trial

NCT06728943

Ureterocopic Lithotripsy Stone Ureter Ureteric Stone

RECRUITING NA

Effect of Perioperative Selective alpha1-blockers in Non-stented Ureteroscopic Laser Lithotripsy for Ureteric Stones: A Randomized Controlled Trial

NCT04557202

Non-stented Ureteroscopic Laser Lithotripsy for Ureteric Stones

COMPLETED PHASE3

Ultrasound Guided Ureteroscopy and Ureteric Stones

NCT03404986

Ureteric Stone

COMPLETED NA

Medical Expulsive Therapy Post-SWL For Renal Stones

NCT05032287

Urologic Diseases Urolithiasis Stone, Kidney

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aminophylline Pain Ureterocopic Lithotripsy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Aminophylline group

Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.

Group Type EXPERIMENTAL

Aminophylline group

Intervention Type DRUG

Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.

Control group

Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.

Group Type PLACEBO_COMPARATOR

Control group

Intervention Type OTHER

Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Aminophylline group

Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.

Intervention Type DRUG

Control group

Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Aged between 18 to 50 years
* American society of anesthesiology (ASA) physical status I - II
* Body mass index (BMI) less than 30.0 kg/m2
* Scheduled for ureteroscopic lithotripsy surgery with D-J ureteric stent placement at the end of procedure
* Under general anesthesia.

Exclusion Criteria

1. Patients with central nervous system diseases, cardiovascular diseases, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction.
2. Pregnancy or lactation.
3. Patients with a history of allergy to aminophylline.
4. Coffee consumption (more than 2 cups/day)
5. Patients with opioid addiction or patients treated with B agonists, tranquilizers, or antidepressants.
6. Short procedures less than 30 minutes or procedures not requiring D-J stent placement.

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No