The Molecular Pathogenesis Study of Cataract

NCT ID: NCT05682001

Last Updated: 2023-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2025-12-30

Brief Summary

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To study the molecular pathogenesis of cataract and explore possible treatments,anterior lens capsules were collected from cataract patients

Detailed Description

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Anterior lens capsules were collected from the patients with DC and ARC, and transparent crystals of cadaveric eyes. M6A epitranscriptomic microarray was performed to investigate the altered m6A modifications and determine the differentially expressed mRNAs. The potential role of dysregulated m6A modification levels was predicted through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Real-time polymerase chain reaction was performed to identify the dysregulated expression of RNA methyltransferases, demethylases, and readers.

Conditions

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Cataract Pathogenesis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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DC group

Anterior lens capsule tissues from DC patients

No interventions assigned to this group

ARC group

Anterior lens capsule tissues from ARC patients

No interventions assigned to this group

NC group

anterior lens capsules collected from three age-matched transparent crystals of cadaveric eyes

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* diabetic cataract
* underwent cataract surgery

Exclusion Criteria

* Combined with other eye diseases
* underwent other eye surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Natural Science Foundation of China

OTHER_GOV

Sponsor Role collaborator

Eye & ENT Hospital of Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Jin Yang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jin Yang, PhD

Role: PRINCIPAL_INVESTIGATOR

Eye & ENT Hospital

Locations

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Eye & ENT Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lei Cai, MD

Role: CONTACT

13816956828

Facility Contacts

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Jin Yang, PhD

Role: primary

13671632525

Other Identifiers

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CMP

Identifier Type: -

Identifier Source: org_study_id

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