Improved Chest CT Diagnostic and Contrast Medium Administration

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

360 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-02

Study Completion Date

2023-01-15

Brief Summary

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Investigation of impact of using different CM approaches on contrast enhancement in chest Ct examinations - A prospective study

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Detailed Description

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Continuing advances in computed tomography (CT) in the past decades such as short scanning times with multi-detector CT (MDCT) requires contrast medium (CM) administration to be precisely planned to ensure a diagnostically accurate CT scans. To improve the chest CT diagnostic, the contrast enhancement in the thoracic vessels shoulde be increased.

The most important patient-related factors affecting the magnitude of vascular and parenchymal contrast enhancement are body weight. Historical practice has been to use a fixed volume of CM independent of body weight. Research has shown a clear relationship between vessel enhancement and patient weight, and that fixed CM volume technique is inappropriate, as smaller patients may receive excessive volume, and larger patients insufficient volume resulting in reduced image quality and poor diagnostic. In addition, excess CM can result in contrast induced adverse effects and nephropathy. To overcome these problems, it is essential to adjust the CM volume to the patient's total body weight and body composition. This adjustment can be done in different ways. The aim of this study is to identify which weight/body tailored CM administration is the best replacement for fixed CM administration in chest CT. The cost and procedure time will also be explored.

Conditions

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Pulmonary Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Two groups receiving contrast medium based on different approaches are included and compared with each other

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Patients receiving contrast enhanced chest CT examination

Study Groups

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Fixed group

They received a fixed amount of contrast media prior to CT scan

Group Type ACTIVE_COMPARATOR

Adopted contrast media amount by using different approaches

Intervention Type OTHER

Using different contrast media approaches recommended by literature to explore the impact on the contrast enhancement in chest CT

body composition tailored group

They received a body tailored amount of contrast media prior to CT scan

Group Type ACTIVE_COMPARATOR

Adopted contrast media amount by using different approaches

Intervention Type OTHER

Using different contrast media approaches recommended by literature to explore the impact on the contrast enhancement in chest CT

Interventions

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Adopted contrast media amount by using different approaches

Using different contrast media approaches recommended by literature to explore the impact on the contrast enhancement in chest CT

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients undergoing chest CT examination between August 2019 and September 2021
* age \> 18 years

Exclusion Criteria

* hemodynamic instability
* cardiac failure
* pacemaker
* renal insufficiency (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
* contraindications to contrast enhanced CT
* age \< 18 years

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No