COMPARISON OF OUTCOMES OF BI-FLANGED METAL STENT ALONE VERSUS BI-FLANGED METAL STENT WITH CO-AXIAL PLASTIC STENT FOR DRAINAGE OF WALLED-OFF PANCREATIC NECROSIS - A PROSPECTIVE RANDOMISED CONTROLLED STUDY.

NCT ID: NCT05632900

Last Updated: 2023-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-17

Study Completion Date

2022-12-20

Brief Summary

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Endoscopic ultrasound guided drainage of WON with metal stent is the mainstay of WON management.

But there are few complications related to BFMS , like bleeding due to vessel erosion, stent clogging , stent migration .

This study is to assess, whether placing an anchoring DPS through the BFMS will decrease adverse events or not.

There are only 2 retrospective studies till date ,comparing LAMS with coaxial stent vs LAMS alone.

one study showed no significant decrease in adverse events , one study showed decrease in adverse events when DPS with LAMS .

But there has been no prospective RCT to assess the utility of DPS to date

Detailed Description

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Inclusion Criteria: -

1. Symptomatic Walled-off pancreatic necrosis (WON)
2. Eligible for EUS guided BFMS placement
3. Signed informed consent .
4. Age \>18 Years

Exclusion Criteria: -

1. Types of pancreatic collections other than WON .
2. Drainage with stents other than BFMS
3. Previous attempts at drainage of WON
4. Coagulopathy (INR\>1.5) or thrombocytopenia(plc \<50000/cmm)- not correctable.
5. Pregnancy
6. Not willing to give informed consent

Conditions

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ENDOSCOPIC ULTRASONOGRAPHY

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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NAGI BI-FLANGED METAL STENT WITH CO-AXIAL PLASTIC STENT FOR DRAINAGE OF WOPN.

Endoscopic ultrasound guided drainage -Nagi Bi Flanged metal stent--16mm diameter 2cm long with co Axial double pig tail stent used for drainage of walled of necrosis. Intra and post prodecural complications will be noted, a plane CT screening abdomen will be performed with in 48 to 72 hours to document the size of collection.

Group Type EXPERIMENTAL

Endoscopic ultrasound guided drainage of walled off pancreatic necrosis

Intervention Type PROCEDURE

It is Therapeutic procedure to treat walled off pancreatic necrosis.

NAGI BI-FLANGED METAL STENT ALONE FOR DRAINAGE OF WOPN.

Endoscopic ultrasound guided drainage -Nagi Bi Flanged metal stent--16mm diameter 2cm long used for drainage of walled of necrosis. Intra and post prodecural complications will be noted, a plane CT screening abdomen will be performed with in 48 to 72 hours to document the size of collection.

Group Type ACTIVE_COMPARATOR

Endoscopic ultrasound guided drainage of walled off pancreatic necrosis

Intervention Type PROCEDURE

It is Therapeutic procedure to treat walled off pancreatic necrosis.

Interventions

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Endoscopic ultrasound guided drainage of walled off pancreatic necrosis

It is Therapeutic procedure to treat walled off pancreatic necrosis.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Symptomatic Walled-off pancreatic necrosis (WON)
2. Eligible for EUS guided BFMS placement
3. Signed informed consent .
4. Age \>18 Years

Exclusion Criteria

1. Types of pancreatic collections other than WON .
2. Drainage with stents other than BFMS
3. Previous attempts at drainage of WON
4. Coagulopathy (INR\>1.5) or thrombocytopenia(plc \<50000/cmm)- not correctable.
5. Pregnancy
6. Not willing to give informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asian Institute of Gastroenterology, India

OTHER

Sponsor Role lead

Responsible Party

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Mohan Ramchandani

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rajesh Dr Gupta, MBBS MD DM

Role: PRINCIPAL_INVESTIGATOR

Asian Institute of Gastroenterology

Locations

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Dr Rajesh Gupta

Hyderabad, Telangana, India

Site Status

Countries

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India

Other Identifiers

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BFMSP -001

Identifier Type: -

Identifier Source: org_study_id

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