Biliary Drainage in Patients With Duodenal Metal Stent

NCT ID: NCT02376907

Last Updated: 2015-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2017-09-30

Brief Summary

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This is a retrospective study to evaluate the outcomes of endoscopic biliary drainage according to the timing of distal malignant biliary obstruction (MBO) in relation to gastric outlet obstruction (GOO) and the location of GOO.

Detailed Description

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This is a multinational multicenter retrospective cohort study to evaluate the outcomes of endoscopic biliary drainage in patients with a duodenal SEMS. Endoscopic ultrasound-guided biliary drainage (EUS-BD), including choledochoduodenostomy, hepaticogastrostomy, antegrade biliary stenting or a combination, and endoscopic retrograde cholangiopancreatography (ERCP) with stenting are to be compared. Specifically, the outcomes are to be evaluated according to the timing of distal MBO in relation to GOO and the location of GOO.

Conditions

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Jaundice

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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EUS-BD or ERCP with duodenal SEMS

Patients who underwent endoscopic placement of a duodenal self-expandable metal stent (SEMS) for nonresectable malignant GOO and endoscopic biliary drainage for nonresectable distal MBO.

Biliary drainage

Intervention Type PROCEDURE

EUS-BD or ERCP

Interventions

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Biliary drainage

EUS-BD or ERCP

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent endoscopic placement of a duodenal SEMS for nonresectable malignant GOO.
* Patients who underwent endoscopic biliary drainage for nonresectable MBO.
* MBO was located ≥ 2 cm from the bifurcation.
* Patients who could be followed up more than three months after completion of both biliary drainage and duodenal SEMS placement.
* Age ≥20 years.
* Irrespective of sex and a primary disease.

Exclusion Criteria

* Patients who underwent surgical bypass for GOO.
* Patients who underwent percutaneous and surgical biliary drainage prior to the placement of duodenal SEMS.
* Patients with altered gastrointestinal anatomy (Billroth-II reconstruction, Roux-en-Y reconstruction, etc.).
* Patients who would not give a consent to the report of their own data.
* Patients considered ineligible for inclusion in the study by an investigator for other reasons.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tokyo University

OTHER

Sponsor Role lead

Responsible Party

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Hiroyuki Isayama, MD, PhD

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hiroyuki Isayama, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Graduate School of Medicine, The University of Tokyo

Locations

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Eastern Hepatobiliary Hospital, Second Military Medical University

Shanghai, , China

Site Status

The Prince of Wales Hospital

Shatin, , Hong Kong

Site Status

Asian Institute of Gastroenterology

Hyderabad, , India

Site Status

Fukushima Medical University

Fukushima, , Japan

Site Status

Gifu University

Gifu, , Japan

Site Status

Onomichi General Hospital

Hiroshima, , Japan

Site Status

Teine-Keijinkai Hospital

Hokkaido, , Japan

Site Status

Sapporo Medical University

Hokkaido, , Japan

Site Status

Hokkaido University School of Medicine

Hokkaido, , Japan

Site Status

Kinki University

Osaka, , Japan

Site Status

Saitama Medical University International Medical Center

Saitama, , Japan

Site Status

Graduate School of Medicine, The University of Tokyo

Tokyo, , Japan

Site Status

Japanese Red Cross Medical Center

Tokyo, , Japan

Site Status

Toho University Ohashi Medical Center

Tokyo, , Japan

Site Status

Kanto Central Hospital

Tokyo, , Japan

Site Status

Tokyo Medical University

Tokyo, , Japan

Site Status

Tokyo Metropolitan Police Hospital

Tokyo, , Japan

Site Status

Prince Court Medical Center

Kuala Lumpur, , Malaysia

Site Status

Singapore General Hospital

Outram Road, , Singapore

Site Status

Changi General Hospital

Simei New Town, , Singapore

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Soon Chun Hyang University School of Medicine

Seoul, , South Korea

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Chulalongkorn University

Bangkok, , Thailand

Site Status

Rajavithi Hospital

Bangkok, , Thailand

Site Status

Countries

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China Hong Kong India Japan Malaysia Singapore South Korea Taiwan Thailand

References

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Maire F, Hammel P, Ponsot P, Aubert A, O'Toole D, Hentic O, Levy P, Ruszniewski P. Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas. Am J Gastroenterol. 2006 Apr;101(4):735-42. doi: 10.1111/j.1572-0241.2006.00559.x.

Reference Type BACKGROUND
PMID: 16635221 (View on PubMed)

Kaw M, Singh S, Gagneja H. Clinical outcome of simultaneous self-expandable metal stents for palliation of malignant biliary and duodenal obstruction. Surg Endosc. 2003 Mar;17(3):457-61. doi: 10.1007/s00464-002-8541-3. Epub 2002 Oct 31.

Reference Type BACKGROUND
PMID: 12404053 (View on PubMed)

Mutignani M, Tringali A, Shah SG, Perri V, Familiari P, Iacopini F, Spada C, Costamagna G. Combined endoscopic stent insertion in malignant biliary and duodenal obstruction. Endoscopy. 2007 May;39(5):440-7. doi: 10.1055/s-2007-966327.

Reference Type BACKGROUND
PMID: 17516351 (View on PubMed)

Moon JH, Choi HJ. Endoscopic double-metallic stenting for malignant biliary and duodenal obstructions. J Hepatobiliary Pancreat Sci. 2011 Sep;18(5):658-63. doi: 10.1007/s00534-011-0409-2.

Reference Type BACKGROUND
PMID: 21655973 (View on PubMed)

Hamada T, Nakai Y, Isayama H, Sasaki T, Kogure H, Kawakubo K, Sasahira N, Yamamoto N, Togawa O, Mizuno S, Ito Y, Hirano K, Toda N, Tada M, Koike K. Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction: an analysis using a time-dependent covariate. Surg Endosc. 2013 Apr;27(4):1243-8. doi: 10.1007/s00464-012-2585-9. Epub 2012 Oct 17.

Reference Type BACKGROUND
PMID: 23073685 (View on PubMed)

Kahaleh M, Hernandez AJ, Tokar J, Adams RB, Shami VM, Yeaton P. Interventional EUS-guided cholangiography: evaluation of a technique in evolution. Gastrointest Endosc. 2006 Jul;64(1):52-9. doi: 10.1016/j.gie.2006.01.063.

Reference Type BACKGROUND
PMID: 16813803 (View on PubMed)

Horaguchi J, Fujita N, Noda Y, Kobayashi G, Ito K, Obana T, Takasawa O, Koshita S, Kanno Y. Endosonography-guided biliary drainage in cases with difficult transpapillary endoscopic biliary drainage. Dig Endosc. 2009 Oct;21(4):239-44. doi: 10.1111/j.1443-1661.2009.00899.x.

Reference Type BACKGROUND
PMID: 19961522 (View on PubMed)

Itoi T, Isayama H, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Tsuji S, Ishii K, Ikeuchi N, Tanaka R, Umeda J, Moriyasu F, Kawakami H. Stent selection and tips on placement technique of EUS-guided biliary drainage: transduodenal and transgastric stenting. J Hepatobiliary Pancreat Sci. 2011 Sep;18(5):664-72. doi: 10.1007/s00534-011-0410-9.

Reference Type BACKGROUND
PMID: 21688214 (View on PubMed)

Kawakubo K, Isayama H, Nakai Y, Sasahira N, Kogure H, Sasaki T, Hirano K, Tada M, Koike K. Simultaneous Duodenal Metal Stent Placement and EUS-Guided Choledochoduodenostomy for Unresectable Pancreatic Cancer. Gut Liver. 2012 Jul;6(3):399-402. doi: 10.5009/gnl.2012.6.3.399. Epub 2012 Jul 12.

Reference Type BACKGROUND
PMID: 22844572 (View on PubMed)

Hamada T, Nakai Y, Lau JY, Moon JH, Hayashi T, Yasuda I, Hu B, Seo DW, Kawakami H, Kuwatani M, Katanuma A, Kitano M, Ryozawa S, Hanada K, Iwashita T, Ito Y, Yagioka H, Togawa O, Maetani I, Isayama H. International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction. Scand J Gastroenterol. 2018 Jan;53(1):46-55. doi: 10.1080/00365521.2017.1382567. Epub 2017 Oct 6.

Reference Type DERIVED
PMID: 28982258 (View on PubMed)

Related Links

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http://www.t-cap.jp/

Tokyo Conference of Asian Pancreato-biliary Interventional Endoscopist

Other Identifiers

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10639

Identifier Type: -

Identifier Source: org_study_id

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