Exercise for Better Bones - Day or Night?

NCT ID: NCT05612412

Last Updated: 2025-04-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 2 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-10-05
• Study Completion Date: 2024-07-30

Brief Summary

The purpose of this study is to find out if moderate exercise at different time during the day (early morning vs early evening) affects biomarker CTX of bone health in normal to overweight postmenopausal women.

Detailed Description

The overall objective of this study is to investigate whether the daily timing of exercise affects bone turnover markers in postmenopausal women. Results from this clinical trial will provide valuable information to support guidelines of physical activity for people to improve musculoskeletal health, especially post-menopausal women. The scientific questions that will be investigated are:

1. What are the acute effects of the daily timing of exercise on serum concentrations of bone turnover markers and 24-h total urinary calcium excretion?

2. Are differences in initial exercise-induced responses of bone turnover markers and urinary Ca excretion maintained across two weeks of exercise training?

Conditions

Overweight

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Morning Exercise

Morning exercise session

Group Type: EXPERIMENTAL

Morning Exercise

Intervention Type: OTHER

Standardized treadmill exercise session starting at approximately 0700

Evening Exercise

Evening exercise session

Group Type: EXPERIMENTAL

Evening Exercise

Intervention Type: OTHER

Standardized treadmill exercise session starting at approximately 1800

Interventions

Morning Exercise

Standardized treadmill exercise session starting at approximately 0700

Intervention Type: OTHER

Evening Exercise

Standardized treadmill exercise session starting at approximately 1800

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Postmenopausal women within 1-10 yr after menopause
• BMI 18.5-29.9 kg/m2
• Healthy as determined by a screening physical examination and blood chemistry related to thyroid, liver, kidney, and lipid profile within normal range
• No osteoporosis as determined by dual energy x-ray absorptiometry (DEXA) scan at femoral neck or total spinal region
• No regular exercise for more than 30 minutes a day on more than 2 days a week and no physically active employment, such as maintenance and repair or delivery worker
• No regular use of medications known to interfere with calcium and bone metabolism from 6 weeks prior to the study to the end of study such as medications for heartburn, reflux, H2 blockers, diuretics, etc. such as antacids, Maalox, Pepcid AC, Nexium, Diuril, etc.
• Weight stable (within 5 lbs change) for at least 3 months prior to the start of the study
• Willing to maintain usual lifestyle and activities including the same wake-sleep schedule (go to sleep between 10:00 p.m. and midnight with an average 6-8 hours of sleep time)
• Refrain from the use of alcohol and nicotine (for example, cigarettes, cigars, and e-cigarettes) for the length of the study
• Able and willing to perform moderate intensity exercise without contraindications as determined by the Physical Activity Readiness Questionnaire
• Willing and able to stop any nutritional supplements including vitamin D supplements and calcium-containing medications (for instance, calcium-carbonate antacids)
• Willing not to use tanning booths during the study or not to travel to locations with a tropical climate two weeks prior to the study or during the washout period

Exclusion Criteria

• Hypertension with resting blood pressure higher than systolic 140 and diastolic 90 mmHg
• Within past 6 weeks, had nutrition supplements or medications known to affect calcium metabolism and appetite such as Antacids, Megace, antacids, heartburn, reflux, H2 blockers, diuretics, etc.
• Allergy to any food ingredients used in the provided diet
• Any disorders affecting nutrient absorption or metabolism, such as cystic fibrosis, lactose intolerance, celiac disease, etc.
• Any sleep disorders such as sleep apnea or regular use of an over-the-counter melatonin supplement
• Diabetes or taking medications known to affect bone such as Actos, Avandia, Invokana, etc.
• Engaged in moderate to vigorous exercise or regular exercise for more than 30 minutes/day on more than 2 days/week within past 6 weeks
• Repeated non-compliance with completing prescribed exercise sessions
• Within past 6 weeks, used tanning booths or traveled to location with a tropic climate
• Use of antibiotics (Amoxicillin, doxycycline, etc.), nonsteroidal anti-inflammatory drugs (aspirin, Celebrex, etc.), or probiotics (Lactobacillus, Bifidobacterium) within the past 6 weeks
• Irritable bowel syndrome, inflammatory bowel disease, or not having a bowel movement three days or longer

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

USDA Grand Forks Human Nutrition Research Center

FED

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jay Cao, PhD

Role: PRINCIPAL_INVESTIGATOR

USDA Grand Forks Human Nutrition Research Center

Locations

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Countries

United States

Provided Documents

Document Type: Informed Consent Form

View Document

Related Links

https://www.ars.usda.gov/plains-area/gfnd/gfhnrc/docs/nutrition-studies/nutrition-studies/

Grand Forks Human Nutrition Research Center Current Nutrition Studies

Other Identifiers

GFHNRC154

Identifier Type: -

Identifier Source: org_study_id