Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2007-05-15
2010-08-19
Brief Summary
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Detailed Description
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Specific aim 1. Measure plasma concentrations of anabolic hormones (parathyroid hormone (PTH) and growth hormone (GH), at sufficient frequency to define the area under the curve (AUC), and of markers of bone formation (osteocalcin, carboxyterminal propeptide of type 1 procollagen (CICP), and bone-specific alkaline phosphatase (ALKP)), and markers of bone resorption (immunoreactive carboxyterminal telopeptide of type I collagen (CTX)) after 40-minutes of treadmill exercise at the relative intensity of 125% of the ventilatory threshold (VT) corresponding to about 1.78 m/sec (4 miles/h), and two intensities of mechanical loading (724, and 1411 N), in healthy postmenopausal women.
Hypothesis 1. Bone formation, as assessed by increases in markers of bone formation and decreases in markers of bone resorption, will be higher in response to dynamic exercise at a level of mechanical loading that produces increased secretion of PTH and GH than to exercise at other loading intensities.
Specific aim 2. Measure plasma concentrations of anabolic hormones), at sufficient frequency to define the area under the curve (AUC), and of markers of bone formation as in specific aim 1, after two 20-minutes of treadmill exercise, separated by 7 h, at the relative intensity of 125% of the ventilatory threshold (VT) corresponding to about 1.78 m/sec (4 mi/h), and two intensities of mechanical loading (724, and 1411 N), in healthy postmenopausal women.
Hypothesis 2. A 7-hour interval separating the two bouts of exercise will have greater bone anabolic effect than the equivalent volume and intensity of exercise performed in a single bout.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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40 minute up trial
Subjects were subjected to 40 minutes of treadmill exercise at a 6 degree incline and at 75% of maximal effort between 8:00 and 8:40 am. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Experimental: 40 minute up trial
40 minute down trial
Subjects were subjected to 40 minutes of treadmill exercise at a 6 degree decline and at 45% of maximal effort between 8:00 and 8:40 am. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Experimental: 40 minute down trial
Two 20 minute up trials
Subjects were subjected to two 20 minutes of treadmill exercise separated by 7 h at a 6 degree incline and at 75% of maximal effort, the first one between 8:00 and 8:40 am and the second one between 15:00 and 15:20 h..Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Experimental: Two 20 minute up trials
Two 20 min down trials
Subjects were subjected to two 20 minutes of treadmill exercise separated by 7 h at a 6 degree incline and at 45% of maximal effort , the first one between 8:00 and 8:40 am and the second one between 15:00 and 15:20 h. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Experimental: Two 20 min down trials
Sedentary trial
No exercise day with isocaloric meals provided at 7:00, 13:00. and 19:00 h.
Active Comparator: Sedentary trial
Interventions
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Experimental: 40 minute up trial
Experimental: 40 minute down trial
Experimental: Two 20 minute up trials
Experimental: Two 20 min down trials
Active Comparator: Sedentary trial
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Dual energy X-ray absorptiometry (DEXA) Z score above -1
* No endocrine or metabolic disease requiring medication except for hormonally corrected hypothyroidism
* No musculo-skeletal disabilities that would preclude treadmill walking
* Normal electrocardiogram (EKG) and heart health history
* BMI between 24 and 30
* Hematocrit above 32 %
* No hormone replacement therapy (HRT)
* Personal health provider's Release Letter
Exclusion Criteria
* Z score below -1
* Medication for presence of metabolic or endocrine disease
* Musculo-skeletal disabilities that would preclude treadmill walking
* Abnormal electrocardiogram (EKG) and heart health history
* Hematocrit below 32%
* Hormone replacement therapy
* Failure to conform to study protocol
50 Years
65 Years
FEMALE
Yes
Sponsors
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University of Wisconsin, La Crosse
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Michigan
OTHER
Responsible Party
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Dr. Katarina Borer
Professor
Locations
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Michigan Clinical Research Unit United States
Ann Arbor, Michigan, United States
Countries
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Other Identifiers
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HUM00007202
Identifier Type: -
Identifier Source: org_study_id
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