Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-12-31

Study Completion Date

2009-12-31

Brief Summary

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We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

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Detailed Description

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Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Conditions

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Osteoporosis Osteopenia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Exercise after fasting

Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions after a 10-hour fast

resistance exercise

Intervention Type OTHER

single bout of resistance exercise

No exercise

Will complete a ten-hour fast but do no exercise

No exercise

Intervention Type OTHER

Will not do any exercise

Exercise after snack

Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions 2 hours following a 500 calorie nutritional supplement

plyometric exercise

Intervention Type OTHER

single bout of plyometric exercise

Interventions

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plyometric exercise

single bout of plyometric exercise

Intervention Type OTHER

resistance exercise

single bout of resistance exercise

Intervention Type OTHER

No exercise

Will not do any exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* No symptoms of disease
* Non-sedentary
* Age 25-65

Exclusion Criteria

* Medications or supplements that affect bone metabolism or prevent exercise
* Previous or current medical condition affecting bone health, including osteoporosis.
* Cardiovascular disease
* Metallic implants affecting accuracy of bone density scan
* Current smoker
* Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes