Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2008-03-31

Brief Summary

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This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

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Detailed Description

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Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.

Conditions

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Feeding Patterns Bone Resorption

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Fasting

Overnight fast

Group Type EXPERIMENTAL

Overnight fast

Intervention Type OTHER

Overnight fast from 21:00 h

Feeding

Normal breakfast

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Overnight fast

Overnight fast from 21:00 h

Intervention Type OTHER

Other Intervention Names

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Fasting

Eligibility Criteria

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Inclusion Criteria

* history of weight bearing exercise
* fasting vitamin D concentration of \>30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of \<6.9 pmol•L-1.