Predictors of OSA in Patients With COPD

NCT ID: NCT05605431

Last Updated: 2023-06-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-03-01
• Study Completion Date: 2020-11-30

Brief Summary

Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea(OSA) are common disorders ,the co-existence of both conditions is called overlap syndrome Smoking , obesity , airway resistance and inflammation are considered risk factors for both conditions ,interestingly either COPD and OSA are associated with increased cardiovascular complications with further increased risk in overlap syndrome Multiple theories could explain that one disorder can predispose or exaggerate the other. For example, in COPD cigarette smoking and inhaled steroids are linked to myopathy of upper airway dilator muscles. Moreover in core-pulmonale redistribution of edema fluid in supine position during sleep can also contribute to or exacerbate OSA .

On the other hand , OSA patients might smoke frequently and more heavily to compensate for excessive daytime sleepiness and to help them to lose weight , which results in exaggerated airway inflammation and exacerbate COPD. Rationale of the study was to assess the prevalence and predictors of OSA among patients with stable COPD.

Conditions

OSA; COPD

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

COPD associated with OSA

Polysomnography

Intervention Type: DIAGNOSTIC_TEST

over nightSleep study

COPD without OSA

Polysomnography

Intervention Type: DIAGNOSTIC_TEST

over nightSleep study

Interventions

Polysomnography

over nightSleep study

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• All stable COPD patients

Exclusion Criteria

• Patients with end organ failure

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 76 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Eman Kamal Ibrahim Hassan

Assistant Professor of pulmonology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Kasr alainy school of medicine

Cairo, , Egypt

Countries

Egypt

Other Identifiers

MS-81-2020

Identifier Type: -

Identifier Source: org_study_id