Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years
NCT ID: NCT05604950
Last Updated: 2022-11-03
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Total Enrollment
2 participants
Study Classification
OBSERVATIONAL
Study Start Date
2009-01-01
Study Completion Date
2022-10-01
Brief Summary
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To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.
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Detailed Description
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Conditions
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Esophageal Squamous Cell Carcinoma
Esophagectomy
Radiotherapy
Chemotherapy
Study Design
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Observational Model Type
COHORT
Study Time Perspective
CROSS_SECTIONAL
Study Groups
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S group
underwent surgical treatment.
Since the data were collected retrospectively, there were no interventions
Intervention Type
DIAGNOSTIC_TEST
Since the data were collected retrospectively, there were no interventions
NS group
underwent non-surgical treatment with RT and/or chemoradiotherapy.
Since the data were collected retrospectively, there were no interventions
Intervention Type
DIAGNOSTIC_TEST
Since the data were collected retrospectively, there were no interventions
Interventions
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Since the data were collected retrospectively, there were no interventions
Since the data were collected retrospectively, there were no interventions
Intervention Type
DIAGNOSTIC_TEST
Eligibility Criteria
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Inclusion Criteria
1. Pathology confirmed ESCC,
2. Patients with esophagectomy or radiotherapy (RT)/chemotherapy (CT),
3. Age ≥ 70.
2. Patients with esophagectomy or radiotherapy (RT)/chemotherapy (CT),
3. Age ≥ 70.
Exclusion Criteria
1. Having other malignant tumours,
2. Missing of required data.
2. Missing of required data.
Minimum Eligible Age
70 Years
Maximum Eligible Age
100 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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Yongtao Han
OTHER
Sponsor Role
lead
Responsible Party
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Yongtao Han
Clinical Professor
Responsibility Role
SPONSOR_INVESTIGATOR
References
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BACKGROUND
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Mohata S, Kumar HS, Sharma N, Jhakhar SL, Beniwal S, Harsh KK. Acute treatment-related toxicity in elderly patients with good performance status compared to young patients in locally advanced esophageal carcinoma treated by definitive chemoradiation: A retrospective comparative study. J Cancer Res Ther. 2020 Jan-Mar;16(1):116-119. doi: 10.4103/jcrt.JCRT_878_18.
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Wang BY, Hung WH, Wu SC, Chen HC, Huang CL, Lin CH, Chen HS. Comparison Between Esophagectomy and Definitive Chemoradiotherapy in Patients With Esophageal Cancer. Ann Thorac Surg. 2019 Apr;107(4):1060-1067. doi: 10.1016/j.athoracsur.2018.11.036. Epub 2018 Dec 17.
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RESULT
Vlacich G, Samson PP, Perkins SM, Roach MC, Parikh PJ, Bradley JD, Lockhart AC, Puri V, Meyers BF, Kozower B, Robinson CG. Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: a review of the National Cancer Database. Cancer Med. 2017 Dec;6(12):2886-2896. doi: 10.1002/cam4.1250. Epub 2017 Nov 15.
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Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
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RESULT
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group. Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial. J Clin Oncol. 2018 Sep 20;36(27):2796-2803. doi: 10.1200/JCO.2018.79.1483. Epub 2018 Aug 8.
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RESULT
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RESULT
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RESULT
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H. Preoperative pembrolizumab combined with chemoradiotherapy for oesophageal squamous cell carcinoma (PALACE-1). Eur J Cancer. 2021 Feb;144:232-241. doi: 10.1016/j.ejca.2020.11.039. Epub 2020 Dec 26.
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RESULT
Rentz J, Bull D, Harpole D, Bailey S, Neumayer L, Pappas T, Krasnicka B, Henderson W, Daley J, Khuri S. Transthoracic versus transhiatal esophagectomy: a prospective study of 945 patients. J Thorac Cardiovasc Surg. 2003 May;125(5):1114-20. doi: 10.1067/mtc.2003.315.
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RESULT
Other Identifiers
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No. 2020YFH0169
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
No. 320.6750.2020-15-3
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
SCCH-TS2022
Identifier Type: -
Identifier Source: org_study_id
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