Heart Failure With Mildly Reduced Ejection Fraction Registry

NCT ID: NCT05603390

Last Updated: 2022-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-01

Study Completion Date

2023-01-01

Brief Summary

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Heart failure (HF) affects about 1% of patients younger than 55 years, whereas the prevalence of HF increases \> 10% in patients with at least 70 years of age. Despite HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the clinical significance of HF with mildly reduced ejection fraction (HFmrEF) has gained more importance within the past years. Those patients are characterized by a left ventricular ejection fraction (LVEF) of 41-49%. However, within the current European guidelines, limited treatment recommendations in this subgroup of HF are yet available as a consequence of the limited number of studies in this field. The "Heart Failure With Mildly Reduced Ejection Fraction Registry" aims to characterize patients with HFmrEF and investigated the prognostic impact of interventional and pharmacological therapies in this subgroup of HF patients.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with HFmrEF (i.e., LVEF 41-49%)
* Patients with at least 18 years of age

Exclusion Criteria

* Patients younger than 18 years of age
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universitätsmedizin Mannheim

OTHER

Sponsor Role lead

Responsible Party

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Michael Behnes

Prof. Dr. med. Michael Behnes

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael Behnes, MD

Role: PRINCIPAL_INVESTIGATOR

First Department of Medicine, University Medical Centre Mannheim, Germany.

Locations

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University Medical Centre Mannheim

Mannheim, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Michael Behnes, MD

Role: CONTACT

+496213836239

Facility Contacts

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Michael Behnes, Prof. Dr. med.

Role: primary

+49 621-383-6239

References

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Reinhardt M, Behnes M, Weidner K, Abumayyaleh M, Lau F, Schmitt A, Abel N, Duerschmied D, Weiss C, Akin M, Akin I, Schupp T. Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large-Scaled Registry. J Am Heart Assoc. 2025 Jan 21;14(2):e033173. doi: 10.1161/JAHA.123.033173. Epub 2025 Jan 16.

Reference Type DERIVED
PMID: 39817535 (View on PubMed)

Other Identifiers

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2022-818

Identifier Type: -

Identifier Source: org_study_id

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