The HUNT for Heart Failure" Risk Score

NCT ID: NCT04648852

Last Updated: 2025-06-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 36511 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-10-01
• Study Completion Date: 2023-06-30

Brief Summary

In this population study aim is to evaluate risk factors for heart failure and combine these into a new heart failure risk score.

Secondly, the heart failure risk score will be internally and externally validated, and compared with established heart failure risk scores. Additionally, the prevalence of heart failure as well as the distribution of the heart failure risk score in the general population will be evaluated.

Detailed Description

Explore which clinical risk factors or patient characteristics in a general population that are associated with increased risk for heart failure events and combine these into a new population-based heart failure risk score ("The HUNT for heart failure risk score") for predicting heart failure risk

Validate the newly developed heart failure risk score internally in the HUNT2 database

Compare the predictive ability of the new heart failure risk score with established heart failure risk scores (the ABC Health HF risk score, the Framingham HF risk score) and an established Norwegian cardiovascular risk score (NORRISK 2)

Estimate the prevalence of likely ("undiagnosed") heart failure , i.e., patients at high risk of HF, in a general population by using both the established heart failure risk scores and the newly developed heart failure risk score, and compare the heart failure event rate between those at high risk of heart failure and those with established heart failure.

Conditions

Heart Failure

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: PROSPECTIVE

Study Groups

Participants in the third wave of the HUNT study

General population participating in the third wave of the HUNT study

Heart failure risk estimation

Intervention Type: OTHER

Evaluation by heart failure risk score

Participants in the second wave of the HUNT study

General population participating in the second wave of the HUNT study

Heart failure risk estimation

Intervention Type: OTHER

Evaluation by heart failure risk score

Interventions

Heart failure risk estimation

Evaluation by heart failure risk score

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Participation in the third or second wave of the HUNT study

Exclusion Criteria

• Not willing to participate
• Missing vital data

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Boehringer Ingelheim

INDUSTRY

Sponsor Role: collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role: collaborator

Vestre Viken Hospital Trust

OTHER

Sponsor Role: collaborator

Helse Nord-Trøndelag HF

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Håvard Dalen, MSc, PhD

Role: STUDY_CHAIR

Helse Nord-Trøndelag HF

Locations

Levanger hospital

Levanger, Norge, Norway

Countries

Norway

References

Ofstad AP, Brunborg C, Johansen OE, Morkedal B, Fagerland MW, Laugsand LE, Gullestad LL, Dalen H. Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score. ESC Heart Fail. 2023 Oct;10(5):2807-2815. doi: 10.1002/ehf2.14390. Epub 2023 May 29.

Reference Type: DERIVED

PMID: 37248650 (View on PubMed)

Other Identifiers

LH-20H4HF

Identifier Type: -

Identifier Source: org_study_id