Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
45 participants
INTERVENTIONAL
2022-11-15
2024-10-20
Brief Summary
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Detailed Description
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To exert fluid loading, 10ml/kg of crystalloid solution will be administered intravenously over 10 minutes. After fluid loading, the SVI will be measured again and fluid responsiveness will be determined according to increment ratio of the SVI.
According to the determined fluid responsiveness, predictive power of pleth variability index and Rainbow pleth variability index for fluid responsiveness will be assessed by building a receiver-operating characteristics curve.
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Study group
Fluid loading, Stroke volume index measurement via transthoracic echocardiography, measurement of pleth variability index and Rainbow pleth variability index, change of tidal volume under mechanical ventilation
Fluid loading
Intravenous administration of 10ml/kg of crystalloids over 10 minutes
Transthoracic echocardiography
Transthoracic echocardiographic measurement of stroke volume index
PVI, RPVI
Continuous measurement of pleth variability index and Rainbow pleth variability index
Tidal volume change
Changing tidal volume for mechanical ventilation as 6, 8, 10 ml/kg
Interventions
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Fluid loading
Intravenous administration of 10ml/kg of crystalloids over 10 minutes
Transthoracic echocardiography
Transthoracic echocardiographic measurement of stroke volume index
PVI, RPVI
Continuous measurement of pleth variability index and Rainbow pleth variability index
Tidal volume change
Changing tidal volume for mechanical ventilation as 6, 8, 10 ml/kg
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Presence of any pulmonary disease
* Decline of enrollment from any of the patient's parents
6 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Hee-Soo Kim
Professor
Principal Investigators
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Hee-Soo Kim, M.D., Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Seoul National University Hospital
Central Contacts
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References
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Gan H, Cannesson M, Chandler JR, Ansermino JM. Predicting fluid responsiveness in children: a systematic review. Anesth Analg. 2013 Dec;117(6):1380-92. doi: 10.1213/ANE.0b013e3182a9557e.
Han YY, Carcillo JA, Dragotta MA, Bills DM, Watson RS, Westerman ME, Orr RA. Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics. 2003 Oct;112(4):793-9. doi: 10.1542/peds.112.4.793.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307.
Other Identifiers
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2209-123-1363
Identifier Type: -
Identifier Source: org_study_id
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