Cognitive Impairments in Psychotic Disorders

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-12

Study Completion Date

2024-05-01

Brief Summary

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Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break

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Detailed Description

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In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.

Conditions

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Psychotic Disorders Cognitive Impairment

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Study Group

Patients diagnosed with psychotic disorder.

DAPAR Tests (IQ equivalent test)

Intervention Type DIAGNOSTIC_TEST

This study will compare DAPAR scores before and after the onset of the psychotic illness.

Control Group

Healthy Controls

DAPAR Tests (IQ equivalent test)

Intervention Type DIAGNOSTIC_TEST

This study will compare DAPAR scores before and after the onset of the psychotic illness.

Interventions

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DAPAR Tests (IQ equivalent test)

This study will compare DAPAR scores before and after the onset of the psychotic illness.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients between the ages 27-18 who had first psychotic break in the last ten years, and more than a year from the date of the DAPAR tests.
* Diagnoses of schizophrenia, Bipolar disorder or Schizoaffective disorder according to DSM-5 criteria.
* Previous DAPAR tests at the age of 17.

* Participants between the ages of 27-18.
* No history of psychotic break.
* Previous DAPAR tests at the age of 17.

Exclusion Criteria

* Participants who did not perform the full battery of the DAPAR tests.
* Participants who have been appointed a guardian.

\- Participants who have a first-degree relative who suffers from a psychotic disorder.

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes