A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities
NCT ID: NCT05574231
Last Updated: 2022-10-10
Study Results
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Basic Information
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NOT_YET_RECRUITING
4000000 participants
OBSERVATIONAL
2022-11-30
2025-12-31
Brief Summary
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* Determine the extent to which periodontitis in registry data is associated with more odontological treatment services and treatment frequency.
* Determine if patients with systemic diseases attend dentists more frequently and receive more treatment services per patient than the population without these diseases.
* Determine to which extent periodontitis and received periodontal treatment affects the risk of medical diseases.
The study will focus on association and trajectories of periodontitis and its treatment with three medical diseases, namely, Type 2 Diabetes Mellitus (Type 2 DM), Cardiovascular Diseases (CVD) and Rheumatoid Arthritis (RA). The dataset consists of approximately 4,000,000 people aged between 18 and 99 years attending private practice in Denmark. The results from PlanPerioMed study are likely to have ramifications for treatment guidelines for other periodontitis comorbidities, e.g. CVD and DM, and will thereby improve the quality of life for a wide range of patients and reduce long-term societal health care expenses related to periodontitis and its comorbidities.
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Detailed Description
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Conditions
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Study Design
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COHORT
OTHER
Interventions
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Periodontal treatment
It includes surgical and non-surgical procedures depending on patient as well as tooth level.
Eligibility Criteria
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Inclusion Criteria
* Self-reported systemic diseases including Diabetes Mellitus Type 2, Cardiovascular Diseases and Rheumatoid Arthritis
* Subjects with Clinical Attachment Loss\>=3mm, Probing Depth \>= 3mm and bleeding on probing (as defined by World Workshop 2017- criteria for periodontitis) in clinical examination will be included in the study population.
Exclusion Criteria
* Subjects with no clinical registrations
18 Years
99 Years
ALL
No
Sponsors
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Plandent A/S
UNKNOWN
University of Copenhagen
OTHER
Responsible Party
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Christian Damgaard
Associate professor, Head of Section
Principal Investigators
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Anne Havemose Poulsen
Role: STUDY_DIRECTOR
Head of Department
Central Contacts
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References
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Kongstad J, Ekstrand K, Qvist V, Christensen LB, Cortsen B, Gronbaek M, Holm-Pedersen P, Holmstrup P, Bardow A, Twetman S, Fiehn NE. Findings from the oral health study of the Danish Health Examination Survey 2007-2008. Acta Odontol Scand. 2013 Nov;71(6):1560-9. doi: 10.3109/00016357.2013.776701. Epub 2013 Apr 29.
Kongstad J, Enevold C, Christensen LB, Fiehn NE, Holmstrup P. Impact of Periodontitis Case Criteria: A Cross-Sectional Study of Lifestyle. J Periodontol. 2017 Jun;88(6):602-609. doi: 10.1902/jop.2017.160426. Epub 2017 Jan 27.
Hansen GM, Egeberg A, Holmstrup P, Hansen PR. Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (from a Danish Nationwide Cohort Study). Am J Cardiol. 2016 Aug 15;118(4):489-93. doi: 10.1016/j.amjcard.2016.05.036. Epub 2016 May 30.
Holmstrup P, Damgaard C, Olsen I, Klinge B, Flyvbjerg A, Nielsen CH, Hansen PR. Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician. J Oral Microbiol. 2017 Jun 14;9(1):1332710. doi: 10.1080/20002297.2017.1332710. eCollection 2017.
Hansen PR, Holmstrup P. Cardiovascular Diseases and Periodontitis. Adv Exp Med Biol. 2022;1373:261-280. doi: 10.1007/978-3-030-96881-6_14.
Joseph R, Rajappan S, Nath SG, Paul BJ. Association between chronic periodontitis and rheumatoid arthritis: a hospital-based case-control study. Rheumatol Int. 2013 Jan;33(1):103-9. doi: 10.1007/s00296-011-2284-1. Epub 2012 Jan 7.
Related Links
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Related Info
Other Identifiers
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522-0018/22-3800
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
522-0018/22-3800
Identifier Type: -
Identifier Source: org_study_id
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