Ultrasound-guided Ilioinguinal/Iliohypogastric Nerve Block

NCT ID: NCT05559437

Last Updated: 2023-10-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-01
• Study Completion Date: 2023-04-20

Brief Summary

Abdominal wall hernias are common, with a prevalence of 1.7% for all ages and 4% for those aged over 45 years. Inguinal hernias account for 75% of abdominal wall hernias, with a lifetime risk of 27% in men and 3% in women. Repair of inguinal hernia is one of the most common operations in general surgery

Detailed Description

The peripheral nerve block usage is increasing in popularity because it decreases pain as estimated by visual analogue scores/numerical rating pain scores postoperatively and decreases the need for postoperative analgesic usage thereby reducing opioid induced side effects like postoperative respiratory depression, nausea, vomiting, NSAID induced gastritis etc. Nerve blocks also shorten Post-Anesthesia Care Unit stay time, and also increases patient satisfaction .

Ultrasound-guided peripheral nerve blocks including ilioinguinal/ iliohypogastric nerve block and transversus abdominis plane block have been widely used and considered as effective traditional techniques for postoperative analgesia in inguinal hernia repair .

In recent years, the quadratus lumborum (QL) block is proposed to be an alternative regional block for both upper abdominal surgery and lower abdominal surgery.

The blockade of ilioinguinal/iliohypogastric nerves in the anterior abdominal wall has improved postoperative analgesia after open inguinal hernia repair and many other procedures.

The Quadratus Lumborum (QL) Block is a regional anesthetic technique which described by anesthesiologist "DR Rafael Blanco" in 2007. Quadratus Lumborum block allows the local anesthetic agent to spread between the posterior aspect of the Quadratus Lumborum muscle and the middle layer of the Thoracolumbar fascia, which is nearer to the thoracic paravertebral space. It has four approaches based on the point of drug deposition in relation to quadratus lumborum muscle. Drug is deposited on the anterolateral, posterior, anterior to the Quadratus Lumborum muscle in the three approaches. In fourth approach drug is deposited intramuscularly. It provides postoperative analgesia for longer duration .

Conditions

Inguinal Hernia Repair; Pain, Postoperative

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Quadratus Lumborum Block group

Quadratus lumborum group (Q) (n=30): patients will receive Quadratus Lumborum Block using 20 mL of 0.25% Levo-bupivacaine

Group Type: EXPERIMENTAL

Levo-bupivacaine 0.25

Intervention Type: DRUG

The blockade of ilioinguinal/iliohypogastric nerves in the anterior abdominal wall has improved postoperative analgesia after open inguinal hernia repair. Other new blocks needs to be investigated

Ilioinguinal/Iliohypogastric Nerve Block group

Ilioinguinal/Iliohypogastric Nerve Block group (I) (n=30): patients will receive Ilioinguinal/Iliohypogastric Nerve Block using 5 mL of 0.25%Levo- bupivacaine

Group Type: EXPERIMENTAL

Levo-bupivacaine 0.25

Intervention Type: DRUG

The blockade of ilioinguinal/iliohypogastric nerves in the anterior abdominal wall has improved postoperative analgesia after open inguinal hernia repair. Other new blocks needs to be investigated

Interventions

Levo-bupivacaine 0.25

The blockade of ilioinguinal/iliohypogastric nerves in the anterior abdominal wall has improved postoperative analgesia after open inguinal hernia repair. Other new blocks needs to be investigated

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. all patients undergoing elective or emergent unilateral inguinal hernia repair

2. Patients scheduled for unilateral inguinal hernia repair

Exclusion Criteria

1. Patient refusal.

2. Contraindication to neuraxial block.

3. neuromuscular diseases (as myopathies, myasthenia gravies).

4. Hematological diseases, bleeding or coagulation abnormality.

5. Uncontrolled Psychiatric diseases,

6. Local skin infection and sepsis at site of the block.

7. Known intolerance to the study drugs.

8. Body Mass Index > 40 Kg/m2,

9. Unstable cardiovascular condition

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Egymedicalpedia

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mona Gad, Assist.Prof

Role: PRINCIPAL_INVESTIGATOR

Department of anesthesia and SICU,Faculty of medicine,Mansoura university , Egypt.

Locations

Mansoura university Hospital

Al Mansurah, , Egypt

Countries

Egypt

Other Identifiers

Mona Gad

Identifier Type: -

Identifier Source: org_study_id