Prevena Spine for Use in Spine Surgery

NCT ID: NCT05555355

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

104 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-01

Study Completion Date

2025-12-01

Brief Summary

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A pilot, prospective, single-center study for the investigation of the use of Prevena Vacuum-Assisted Closure devices in patients undergoing spine surgery.

Detailed Description

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The objective of the study is to evaluate the efficacy of the Prevena Plus 125 therapy Unit (KCI USA, Inc.) in preventing surgical site infections and other wound complications in patients undergoing spine surgery compared to conventional wound dressing. Furthermore, the investigators want to illustrate which patients benefit most significantly from Prevena usage as spine surgery sees a range of potential candidates, and not all may experience equivalent recovery from spine surgery with Prevena intervention.

Conditions

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Surgery Incision, Surgical

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Single center study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1 (control)

Prospective control of patients who did not use Prevena following spine surgery.

Group Type PLACEBO_COMPARATOR

Spine surgery

Intervention Type PROCEDURE

Patients will receive spine surgery

Group 2 (Prevena)

Prospective group of patients receiving spine surgery who will have Prevena applied to incision area.

Group Type ACTIVE_COMPARATOR

Prevena Plus 125 Therapy Unit

Intervention Type DEVICE

The investigators will utilize the KCI USA, Inc Prevena Plus 125 vacuum-assisted closure device in patients undergoing spine surgery as a method to prevent surgical site infections and wound dehiscence after surgery. The device has been approved by the FDA under the name "Prevena 125 and Prevena Plus 125 Therapy Units" and regulation number 21CFR 878.4783.

Spine surgery

Intervention Type PROCEDURE

Patients will receive spine surgery

Interventions

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Prevena Plus 125 Therapy Unit

The investigators will utilize the KCI USA, Inc Prevena Plus 125 vacuum-assisted closure device in patients undergoing spine surgery as a method to prevent surgical site infections and wound dehiscence after surgery. The device has been approved by the FDA under the name "Prevena 125 and Prevena Plus 125 Therapy Units" and regulation number 21CFR 878.4783.

Intervention Type DEVICE

Spine surgery

Patients will receive spine surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Patients undergoing spinal fusion surgery
2. Over 18 years old

Exclusion Criteria

1. Medical or psychiatric condition that may increase the risk with study participation, may complicate patient compliance, or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the subject inappropriate for entry into this study
2. Subjects who are pregnant at the date of surgery (SOC for surgery)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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3M

INDUSTRY

Sponsor Role collaborator

Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Robert Galiano

Associate Professor of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Northwestern Memorial Hospital

Chicago, Illinois, United States

Site Status

Countries

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United States

Other Identifiers

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STU00216293

Identifier Type: -

Identifier Source: org_study_id

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