Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
20 participants
OBSERVATIONAL
2022-10-31
2022-10-31
Brief Summary
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Detailed Description
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In addition to the deterioration in patients' quality of life, the economic cost for the health care system is very high, in particular because of prolonged hospitalizations, complex treatments, and frequent readmissions. Thus, the adequate management of PJI is a major public health issue.
In this context, new therapeutic approaches are urgent medical needs for the management of patients with PJI.
Thus, the identification of the biological mechanisms (immunology, microbiology, bone physiology) underlying these infections is essential. Indeed, the impact of bacterial infections on bone homeostasis is poorly documented. Although several biological mechanisms have been suggested the host-pathogen interaction and the close links between bacterial infection and biological response of bone cells to microorganisms and their environment warrant to be explored.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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septic samples
patients undergoing revision surgery for prosthetic joint infection
No interventions assigned to this group
aseptic samples
patients undergoing revision surgery for prosthetic replacement without infection
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patient eligible for lower limb revision surgery (revision surgery for infected or non-infected prosthesis)
* Patient affiliated to a social security system
* Oral consent to the research
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Martine COHEN-SOLAL, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Locations
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Hôpital Lariboisière
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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APHP220417
Identifier Type: -
Identifier Source: org_study_id
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