Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk Patients

NCT ID: NCT03848091

Last Updated: 2024-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-01

Study Completion Date

2018-01-01

Brief Summary

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One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.

This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant.

Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.

Detailed Description

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Conditions

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Prosthetic Joint Infection Antibiotic Resistant Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Antibiotic pretreatment

patients having had an antibiotic pretreatment before a one-step exchange arthroplasty

Antibiotic pretreatment

Intervention Type OTHER

a strategy with antibiotic pretreatment before one-step exchange arthroplasty in patients who bacteria responsible for the infection has been indentified (puncture, blood cultures,...)

Interventions

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Antibiotic pretreatment

a strategy with antibiotic pretreatment before one-step exchange arthroplasty in patients who bacteria responsible for the infection has been indentified (puncture, blood cultures,...)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients having had a antibiotic pretreatment targeted before a one step exchange arthroplasty

Exclusion Criteria

* none
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Eugénie MABRUT

CRA

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tristan Ferry, Md,PhD

Role: PRINCIPAL_INVESTIGATOR

HCL

Locations

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Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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18-030

Identifier Type: -

Identifier Source: org_study_id

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