Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
5 participants
INTERVENTIONAL
2022-09-01
2025-08-24
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
NCT06476795
Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans
NCT03587883
Effects of California Walnuts on Vascular Function in Postmenopausal Women
NCT01072864
Effect of Long Term Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 1
NCT02447770
Acute Assessment of Platelet Reactivity After the Intake of Oleocanthal
NCT03528603
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
OTHER
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Low Flavanol Cocoa Powder
12 g of Low Flavanol Cocoa Powder (30 mg of cocoa flavanols) provided as a beverage mixed in water
High Flavanol Cocoa Powder
Measure the response 2 and 6 hours post high flavanol cocoa intake
Vine to Bar Chocolate - 2 servings
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate - 1 serving
Measure the response 2 and 6 hours post chocolate intake
High Flavanol Cocoa Powder
High Flavanol Cocoa Powder (435 mg of flavanols) will be provided as a beverage mixed in water.
Low Flavanol Cocoa Powder
Measure the response 2 and 6 hours post low flavanol cocoa intake
Vine to Bar Chocolate - 2 servings
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate - 1 serving
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate covered almonds
Measure the response 2 and 6 hours post chocolate covered almond intake
Two Servings of Vine to Bar Chocolate
Two servings (60g, 6 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.
Vine to Bar Chocolate - 1 serving
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate covered almonds
Measure the response 2 and 6 hours post chocolate covered almond intake
One Serving of Vine to Bar Chocolate
A single serving (30g, 3 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.
Low Flavanol Cocoa Powder
Measure the response 2 and 6 hours post low flavanol cocoa intake
High Flavanol Cocoa Powder
Measure the response 2 and 6 hours post high flavanol cocoa intake
Vine to Bar Chocolate - 2 servings
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate covered almonds
Measure the response 2 and 6 hours post chocolate covered almond intake
Vine to Bar Chocolate covered Almonds
11 pieces (45g) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc, with almonds
Vine to Bar Chocolate - 2 servings
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate - 1 serving
Measure the response 2 and 6 hours post chocolate intake
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Low Flavanol Cocoa Powder
Measure the response 2 and 6 hours post low flavanol cocoa intake
High Flavanol Cocoa Powder
Measure the response 2 and 6 hours post high flavanol cocoa intake
Vine to Bar Chocolate - 2 servings
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate - 1 serving
Measure the response 2 and 6 hours post chocolate intake
Vine to Bar Chocolate covered almonds
Measure the response 2 and 6 hours post chocolate covered almond intake
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Subject is willing and able to comply with the study protocols.
* Subject is willing to participate in all study procedures
* BMI 25.0 - 35 kg/m2
Exclusion Criteria
* Indivduals that weight less than a 110 lbs
* Donation of blood within the previous 30 days
* Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0
* 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%.
* Platelet counts \< 150,000 / ul
* Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.
* Dislike or allergy for nuts, cocoa or grape products
* Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
* Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
* Fruit consumption ≥ 3 cups/day
* Vegetable consumption ≥ 4 cups/day
* Nut intake ≥ 2 servings/ week
* Coffee/tea ≥ 3 cups/day
* Dark chocolate ≥ 3 oz/day
* Self-reported restriction of physical activity due to a chronic health condition
* Self-reported chronic/routine high intensity exercise
* Self-reported diabetes
* Blood pressure ≥ 140/90 mm Hg
* Self-reported renal or liver disease
* Self-reported heart disease, which includes cardiovascular events and stroke
* Peripheral artery disease, Raynaud's syndrome
* Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT
* Self-reported cancer within past 5 years
* Self-reported malabsorption
* Currently taking prescription drugs or supplements.
* Supplement use or unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
* Indications of substance or alcohol abuse within the last 3 years
* smoking, vaping, cannabis use
* Current enrollee in a clinical research study.
30 Years
50 Years
MALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of California, Davis
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Carl L Keen
Role: PRINCIPAL_INVESTIGATOR
Distinguished Professor Emeritus of Nutrition
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Academic Surge, University of California, Davis
Davis, California, United States
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
1810396
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.