High-density Activation Mapping of the Slow Pathwayto Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia

NCT ID: NCT05531903

Last Updated: 2024-04-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 119 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-15
• Study Completion Date: 2023-09-01

Brief Summary

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia inducible during an electrophysiological study. Although ablative therapy proved to be the treatment of choice, little is known about the components of the tachycardia circuit. The aim of this study is to detect the presence and patterns of specific electrograms representing slow pathway (SP) potentials and to explore Koch's triangle pattern activation during sinus rhythm and/or atrial extraestimulus with a high-density mapping catheter in an attempt to clarify a fast and safety catheter ablation strategy. We hypothesized that, in patients with dual atrioventricular nodal physiology, during sinus rhythm (SR), high-density mapping (HDM) catheters could identify the SP signals, making possible to delineate small areas of slow conduction associated to abnormal electrograms on Koch's triangle. On a second step, radiofrequency (RF) applications safety guided by the HDM obtained with this method, should interrupt the circuit far from the His region. Finally, SP signals should disappear after the RF procedure when performing a new 3D HDM. A control group of patients without AVN dual physiology should show absence of fragmented/slow conduction zones.

Conditions

Supraventricular Tachycardia; Atrioventricular Nodal Re Entrant Tachycardia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Patients with atrioventricular node reentrant tachycardia

Patient with documented AVNRT and fragmented/slow conduction zones observed in a 3D high density mapping

Group Type: EXPERIMENTAL

Description of Slow pathway signals to facilitate ablation

Intervention Type: DEVICE

3D endocardial mapping in order to identify slow pathway signals and abolish or modificate them after radiofrequency ablation

Interventions

Description of Slow pathway signals to facilitate ablation

3D endocardial mapping in order to identify slow pathway signals and abolish or modificate them after radiofrequency ablation

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Patients > 18 yo with AVNRT observed after electrophysiological study

Exclusion Criteria

• Patients < 18 yo

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Parc de Salut Mar

OTHER

Sponsor Role: lead

Responsible Party

Jesus Ignacio Jimenez Lopez

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jesús Ignacio Jimenez López, MD

Role: PRINCIPAL_INVESTIGATOR

Parc de Salut Mar

Locations

Jesús Ignacio Jiménez López

Barcelona, , Spain

Countries

Spain

Other Identifiers

CEIm 2022/10521

Identifier Type: -

Identifier Source: org_study_id