Modification of the Local Abnormal Ventricular Activity Only

NCT ID: NCT05331716

Last Updated: 2022-10-07

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 22 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-01-01
• Study Completion Date: 2021-12-31

Brief Summary

Local abnormal ventricular activity (LAVA) is composed of high-frequency, mainly low voltage signals that represent near-field signals from slow-conducting tissue and thus potential VT isthmuses. The identification of LAVA potentials and their modification have usually been a complimentary component of the substrate-based modification of scar related ventricular arrhtyhmias. With better identification through technical solutions and improved algorithms, LAVA modification may be feasible for treatment in therapy refractory VT.

Detailed Description

As of 2019 we started LAVA modification only in a subset of patients with therapy refractory ventricular tachycardia. The cohort icludes 55% patient with ischemic cardiomyopathy and 45% with dilated cardiomyopathy. 80% are ICD recipients. These patients were now retrospectively analysed in depth. The endpoint is time to relapse of ventricular tachycardia or ICD shock or death due to malignant arrhythmia. We evaluated all patients we treated accordingly from March 2019 through October 2020. No patient was excluded.

Conditions

Ventricular Tachycardia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

Cardiac ablation therapy

In a subset of patients with known therapy refractory arrhythmia sole LAVA modification is fashioned

Intervention Type: PROCEDURE

Other Intervention Names

LAVA modification

Eligibility Criteria

Inclusion Criteria

therapy refractory ventricular arrhythmia

Exclusion Criteria

none

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Krankenhaus Landshut Achdorf

UNKNOWN

Sponsor Role: collaborator

University of Kiel

OTHER

Sponsor Role: lead

Responsible Party

Prof. Dr. Hendrik Bonnemeier

Coordinating principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hendrik Bonnemeier, PhD

Role: STUDY_DIRECTOR

University of Kiel - Medical Faculty

Stefan Borov, MD

Role: PRINCIPAL_INVESTIGATOR

University of Kiel - Medical Faculty

Locations

Krankenhaus Landshut Achdorf

Landshut, Bavaria, Germany

Countries

Germany

Other Identifiers

2021-1232

Identifier Type: -

Identifier Source: org_study_id